Potential of Manuka Honey as a Natural Polyelectrolyte to Develop Biomimetic Nanostructured Meshes With Antimicrobial Properties
Creators
- 1. University of Leeds
- 2. Ulster University
- 3. Politecnico di Torino
- 4. Universita' del Piemonte Orientale "A.Avogadro"
- 5. Newcastle University
Description
The use of antibiotics has been the cornerstone to prevent bacterial infections; however, the
emergency of antibiotic resistant bacteria is still an open challenge. This work aimed to develop a
delivery system for treating soft tissue infections for: (1) reducing the released antimicrobial amount,
preventing drug-related systemic side effects, (2) re-discovering the beneficial effects of naturally
derived agents, and (3) preserving the substrate functional properties. For the first time Manuka
honey (MH) was proposed as polyelectrolyte within the layer-by-layer (LbL) assembly. Biomimetic
electrospun poly(ε-caprolactone) meshes were treated via LbL assembly to obtain a multilayered
nanocoating, consisting of MH as polyanion and poly-(allylamine-hydrochloride) as polycation.
Files
Frontiers_Manuscript_111019.pdf
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Additional details
Funding
- UK Research and Innovation
- EPSRC-NIHR HTC Partnership Award: IMPRESS Network, Incontinence Management and Prevention through Engineering and Sciences EP/M000109/1
- UK Research and Innovation
- EPSRC-NIHR HTC Partnership Award 'Plus': IMPRESS EP/N027345/1
- European Commission
- PROM – Pregnancy and Reproduction Organ-on-a-chip Models 748903