Significance of the proper acclimatization, use of the acetazolamide and dexamethasone in prevention of acute mountain sickness (AMS) – literature review

Mazur Karol, Machaj Dominik, Jastrzębska Sandra, Płaczek Alicja, Mazur Dominika. Significance of the proper acclimatization, use of the acetazolamide and dexamethasone in prevention of acute mountain sickness (AMS) – literature review. Journal of Education, Health and Sport. 2020;10(2):66-73. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.02.008

https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.02.008

https://zenodo.org/record/3661456

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

© The Authors 2020;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

 The authors declare that there is no conflict of interests regarding the publication of this paper.

 Received: 15.01.2020. Revised: 25.01.2020. Accepted: 10.02.2020.

Significance of the proper acclimatization, use of the acetazolamide and dexamethasone in prevention of acute mountain sickness (AMS) – literature review

Karol Mazur, Dominik Machaj, Sandra Jastrzębska, Alicja Płaczek, Dominika Mazur

Karol Mazur, mazurkarol79@gmail.com, Faculty of Medicine, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin, Poland

Dominik Machaj, dominik5a4@tlen.pl, Faculty of Medicine, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin, Poland

Sandra Jastrzębska, sandra0189@gmail.com, Faculty of Medicine, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin, Poland

Alicja Płaczek, alicja60@poczta.onet.pl, Medical Faculty, University of Rzeszow, Pigonia Street 6, 35-310 Rzeszow, Poland

Dominika Mazur, dominika.hul20@gmail.com, Medical Faculty, University of Rzeszow, Pigonia Street 6, 35-310 Rzeszow, Poland

Summary:

Acute mountain sickness (AMS) is an ilness, that occurs in non-acclimatized individuals after rapid ascent to high altitude, typically above 2,500 metres (8,000 ft). The main causes of the AMS are: reduced air pressure and lower oxygen levels at high altitudes. The early symptoms of AMS are non-specific such as: headache, anorexia, nausea, vomiting, fatigue, dizziness, and sleep disturbance, but not all need to be present at one time. It is very important to recognise the early symptoms of AMS and to start the treatment, because untreated AMS can progress to the life‐threatening: high altitude cerebral edema (HACE) and high altitude pulmonary edema (HAPE). Treatment of AMS consists of stabilization of the patient conditon, descent to lower altitude, oxygen therapy and administering acetazolamide and dexamethasone. The aim of this study was to evaluate the significance of the proper acclimatization, use of the acetazolamide and dexamethasone in prevention of acute mountain sickness (AMS).

Proper acclimatization, use of the acetazolamide and dexamethasone are highly effective  in prevention of occurrence and reducing the symptoms of acute mountain sickness (AMS). Pharmacological prophylaxis is not necessary in low-risk situations but should be considered in addition to gradual ascent for use in moderate- to high-risk situations  Acetazolamide should be strongly considered in climbers and travelers at moderate or high risk of AMS with ascent to high altitude. Dexamethasone can be used as an alternative in individuals with a history of intolerance of or allergic reaction to acetazolamide. In rare circumstances (eg, military or rescue teams that must ascend rapidly to and perform physical work at >3500 m), consideration can be given to concurrent use of acetazolamide and dexamethasone.

Key words: acute mountain sickness, AMS, acclimatization, acetazolamide, dexamethasone