Maternal and fetal genome wide association study of total 25-hydroxyvitamin D levels measured in a cohort of mother-newborn pairs
Creators
- 1. Department of Psychiatry, Institute for Human Genetics, University of California, San Francisco, CA
- 2. California Department of Public Health, Richmond, CA
- 3. Sequoia Foundation, La Jolla, CA
- 4. Queensland Brain Institute, University of Queensland, Brisbane, Australia
- 5. Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA
- 6. A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA,
- 7. Kaiser Permanente Division of Research, Oakland, CA
Description
Prenatal vitamin D deficiency may increase the risk of adverse outcomes in newborns, such as autism and intellectual disability. We studied the genome-wide contribution to maternal and neonatal total vitamin D. We identified a significant association between the fetal GC locus and neonatal vitamin D levels. We also found suggestive loci near immune genes and a suggestive interaction between neonatal vitamin D, intellectual disability, and a maternal SNP. Our results shed light on the genetic control of vitamin D in pregnancy and at birth via neonatal proteins of vitamin D metabolism, but also potentially via distinct immunological mechanisms.
We report here the summary statistics for the first study of the genetic impact on levels of total 25-hydroxyvitamin D (D2 and D3) in a cohort of maternal-neonatal pairs. We were able to account for maternal genetic control of mid-gestational vitamin D levels and fetal genetic control of neonatal vitamin D levels at birth. Additionally, due to our unique cohort, we were able to investigate cross-genetic models to determine whether maternal genetics influence neonatal vitamin D and whether fetal genetics might play a role in maternal vitamin D physiology.
Table1_neonatal_vitaminD_fetal_genetics.stats.csv.gz
Summary statistics for GWAS analysis of fetal genetic contribution to neonatal vitamin D.
Table2_maternal_vitaminD_maternal_genetics.stats.csv.gz
Summary statistics for GWAS analysis of maternal genetic contribution to maternal mid-gestational vitamin D.
Table3_neonatal_vitaminD_maternal_genetics.stats.csv.gz
Summary statistics for GWAS analysis of maternal genetic contribution to neonatal vitamin D.
Table4_maternal_vitaminD_fetal_genetics.stats.csv.gz
Summary statistics for GWAS analysis of fetal genetic contribution to maternal mid-gestational vitamin D.
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