Published November 7, 2019 | Version v1
Journal article Open

Nonsteroidal anti-inflammatory drugs– What do we (not) know about them

Creators

  • 1. Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • 2. Health Service, Gorna Malina, Bulgaria
  • 3. Faculty of Chemistry and Pharmacy, Sofia University "St. Kliment Ohridski", Sofia, Bulgaria
  • 4. Department of Pharmacology, Faculty of Pharmacy, Faculty of Pharmacy, Izmir, Turkey
  • 5. Rigas Stradin University, Riga, Latvia
  • 6. Institute of Physical Chemistry "Ilie Murgulescu", Bucharest, Romania
  • 7. Faculty of Chemistry and Chemical Technology, University of Lubljana, Lubljana, Slovenia
  • 8. Faculty of Biology, Sofia University "St. Kliment Ohridski", Sofia, Bulgaria

Description

Nonsteroidal anti-inflammatory drugs (NSAIDs) reversibly inhibit the functioning of cyclooxygenase (COX) – the rate-limiting enzyme in prostaglandin synthesis, and express anti-inflammatory, antipyretic and analgesic effects. NSAIDs are among the most widely used medications in the world and are prescribed for the treatment of various forms of chronic and acute pain, arthritic conditions, rheumatism, fever/pyrexia, gout, etc. Some of them (aspirin) are used also for prevention of secondary cardiovascular disease due to their ability to suppress platelet aggregation. The mini-review summarizes data about mechanism(s) of action, clinical application and side effects/toxicity of these drugs as well as their potential antitumor activity.

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