Dendritic action potentials and computation in human layer 2/3 cortical neurons
Creators
- 1. Institute for Biology, Humboldt-Universität zu Berlin, Berlin, Germany
- 2. Epilepsy-Center Berlin-Brandenburg, Department of Neurology, Charité - Universitätsmedizin Berlin, Germany
- 3. Institute of Integrative Neuroanatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany
- 4. Institute of Molecular Biology and Biotechnology-Foundation for Research and Technology Hellas (IMBB-FORTH), Crete, Greece
- 5. Institute of Integrative Neuroanatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany and NeuroCure Cluster, Charité - Universitätsmedizin Berlin, Germany
Description
The active electrical properties of dendrites shape neuronal input and output and are fundamental to brain function. However, our knowledge of active dendrites has been almost entirely acquired from studies of rodents. In this work, we investigated the dendrites of layer 2 and 3 (L2/3) pyramidal neurons of the human cerebral cortex ex vivo. In these neurons, we discovered a class of calcium-mediated dendritic action potentials (dCaAPs) whose waveform and effects on neuronal output have not been previously described. In contrast to typical all-or-none action potentials, dCaAPs were graded; their amplitudes were maximal for threshold-level stimuli but dampened for stronger stimuli. These dCaAPs enabled the dendrites of individual human neocortical pyramidal neurons to classify linearly nonseparable inputs—a computation conventionally thought to require multilayered networks.
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Additional details
Related works
- Is cited by
- Journal article: 10.1126/science.aax6239 (DOI)
Funding
- European Commission
- ActiveCortex - Active dendrites and cortical associations 670118
- European Commission
- DEMORY - Dissecting the Role of Dendrites in Memory 311435
- European Commission
- DESIRE - Development and Epilepsy - Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy 602531