Prolactin – friendly lactation hormone or hostile cancerogenic factor?

Leziak Milena, Niedobylski Sylwiusz, Żak Klaudia, Skórzyńska-Dziduszko Katarzyna, Krasowska Danuta. Prolactin – friendly lactation hormone or hostile cancerogenic factor? Journal of Education, Health and Sport. 2019;9(9):247-252. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3401873

http://ojs.ukw.edu.pl/index.php/johs/article/view/7390

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

© The Authors 2019;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

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The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 25.08.2019. Revised: 30.08.2019. Accepted: 07.09.2019.

Prolactin – friendly lactation hormone or hostile cancerogenic factor?

Milena Leziak, mail: milena.leziak@wp.pl, ORCID : https://orcid.org/0000-0001-9911-5534 (1),

Sylwiusz Niedobylski, mail: sniedobylski@gmail.com, ORCID : https://orcid.org/0000-0001-7266-623X (1),

Klaudia Żak, mail: zakklaudia3@gmail.com,
ORCID : https://orcid.org/0000-0003-2421-2553 (1),

Katarzyna Skórzyńska-Dziduszko, mail: katarzynaskorzynskadziduszko@umlub.pl, ORCID: http://orcid.org/0000-0002-8718-1187 (2),
Danuta Krasowska, mail: dana.krasowska@gmail.com (3)

1 - Studenckie Koło Naukowe przy Katedrze i Zakładzie Fizjologii Człowieka Uniwersytetu Medycznego w Lublinie, Polska

2 - Katedra i Zakład Fizjologii Człowieka Uniwersytetu Medycznego w Lublinie, Polska

3 - Studenckie Koło Naukowe przy Zakładzie Psychologii Stosowanej, Uniwersytet

Medyczny w Lublinie, Polska

Abstract

Prolactin is a hormone secreted by lactotrophic cells of the pituitary gland and its main function is stimulating lactation. Binding prolactin by its membrane receptor leads to the activation of signalling pathway that enables cell proliferation and differentiation. Due to this mechanism, the potential oncogenic role of the hormone is of great interest. Prolactin and its receptor have many forms and a complicated signalling pathway, that is why defining prolactin’s specific role in cancerogenesis is difficult and poses a serious challenge. Researches also indicate an important role of extra-pituitary prolactin synthesised in many other tissues in the process of cancerogenesis. This article focuses on connection between prolactin and breast cancer, as it is the most common cancer in women. In several studies, prolactin and its receptor were significantly associated with an increased breast cancer risk. Recent research papers focus also on the treatment of breast cancer, using knowledge about prolactin and its role in the development of the tumour.

Key words: prolactin; breast cancer;