Published May 2, 2019
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Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease
Description
We used a functional MRI paradigm involving conventional vs. unconventional views of
objects to assess bottom-up vs. top-down visual processing in Parkinson’s disease (PD) with
normal cognition, PD with mild cognitive impairment (MCI), and MCI due to Alzheimer’s
disease (AD) as compared to healthy controls. We particularly aimed at determining whether
the task discriminated between PD with and without MCI and between two MCI groups due
to distinct pathologies (AD and PD).
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