Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde

Prokopchuk Elena, Aleksandrova Alexandra, Kravchenko Iryna. Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde. Journal of Education, Health and Sport. 2019;9(2):156-164. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2561182

http://ojs.ukw.edu.pl/index.php/johs/article/view/6572

https://pbn.nauka.gov.pl/sedno-webapp/works/903551

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017).

1223 Journal of Education, Health and Sport eissn 2391-8306 7

© The Authors 2019;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 25.01.2019. Revised: 30.01.2019. Accepted: 10.02.2019.

Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde

Elena Prokopchuk, Alexandra Aleksandrova, Iryna Kravchenko

Odessa National Polytechnic University, Shevchenko Avenue 1, Odessa, Ukraine

Prokopchuk

e-mail pochtawt@me.com

ORCID: 0000-0002-7060-1755

Aleksandrova

e-mail aleksa713135@gmail.com

ORCID: 0000-0002-5930-6843

Kravchenko

e-mail kisimishca@yahoo.com

ORCID: 0000-0001-8929-8701

Conflict of Interest: The authors declare that they have no conflict of interest

Abstract

The physiological role of pain helps to avoid or limit the tissue damage and therefore it provides the vital protective function. It has been previously studied, that complex compounds SnCl₄ with salicyloylhydrazones of benzaldehyde and brombenzaldehyde as well as their components represent the practical interest by the manifestation of anti-inflammatory and antidepressive action. In this case the analgesic properties of the complexes themselves, as well as compounds belonging to their structure were of interest of our study. The experiments were performed on white mice. Several chemical (allyl isothiocyanate or AITC, capsaicin, formalin) and thermal effects have been chosen in this investigation for studying the analgesic activity and establishing the possible mechanisms of antinociceptive effect.

The tested compounds showed a mixed type of receptor interaction using models with different types of stimulation, which allows to make conclusions about their perspective as highly effective analgesics with a complex mechanism of action.

Key words: anti-inflammatory, AITC, stannous chloride, salicyloylhydrazones, brombenzaldehyde, benzaldehyde