EVALUATION OF ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITIES OF KYLLINGA TRICEPS ROTTB. RHIZOMES IN CARBON TETRA CHLORIDE-INTOXICATED RATS

The anti oxidant and hepato protective activities of the extract of kyllinga triceps rottb. Rhizome were investigated against ccl4-induced hapatotoxicity in rats. Hepatotoxic rats were treated with eathanol and pet. Ether extracts of rhizome of kyllinga triceps with two dose levels 100 mg/kg and 200 mg/kg body weight/day, orally. The activities were studied by assaying the serum marker enzymes like SGOT, SGPT, ALP and ACP as well as total Bilirubin (mg/100 ml) of blood, was also estimated. All the biochemical Investigations were confirmed by the histopatholoigical observations and compared with the standard drug sillymarin. Antioxidant activity is evaluated by estimations of SOD, catalase, glutathione peroxidase TBRARS, result suggest significant hepatoprotective and antioxidant effects of the plant rhizomes which might be due to the presence of terpenes and terpenoides. As diterpene is isolated from the ethanolic extract of kyllinga triceps rhizomes.