Formulation And Evaluation Of Once Daily Ciprofloxacin Hcl Extended Release Matrix Tablet

Ciprofloxacin HCl has invitro activity against a wide range of gram – negative and gram – positive organisms. The bactericidal action of Ciprofloxacin HCl results from inhibit the enzyme bacterial DNA gyrase (topoisomerase II ).The main objective of this research work was to prepare Ciprofloxacin HCl matrix tablet using HPMC as the polymer and invitro drug release study. In the present study wet granulation method is used for preparing the matrix tablet. Different grades of HPMC were used for the formulation such as, HPMCK 100 LVEP, HPMC K 4M, HPMC E10MCR, HPMC K15M, HPMCK100M. During preparation, all powders were mixed and are then passed through 60# sieve and then granulated using PVP 30 in Isopropyl alcohol and are dried for 2 hours and again passed through 16# sieve. The dried granules were then mixed in poly bag using magnesium stearate and talc. Granules were then punched using rotary tablet machine .The extended release matrix tablet were subjected to in vitro release using USP 2 apparatus. Formulation F14 shows 99.36 % drug release in 24th hour. Stability studies were performed for optimized batch. The optimized formulation F14 showed better stability when stored at 40◦c under 75% RH for one month. From similarly factor F2 of F 14 trial batch shows that dissolution profile matches with the marketed product Cifran. Thus it is concluded that HPMC matrix tablet of Ciprofloxacin can be prepared by Wet granulation method and invitro release data is satisfactory.