Published January 31, 2013
| Version v1
Journal article
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EFFECT OF SOLUBILITY ENHANCERS ON THE SOLUBILITY OF PARACETAMOL
Creators
- 1. 1 Department of Pharmaceutics, SVPMS College of Pharmacy, Malegaon Bk, Taluka Baramati District Pune 413115 2 Department of Pharmaceutical Analysis, SVPMS College of Pharmacy, Malegaon Bk, Taluka Baramati District Pune 413115 3Department of Pharmaceutical Chemistry, SVPMS College of Pharmacy, Malegaon Bk, Taluka Baramati District Pune 413115
Description
Solubility plays an important role in dissolution and absorption of drug. Paracetamol has less solubility in aqueous media and belongs to class IV drug according to biopharmaceutical classification system.The aim of present study was to study the effect of different solubility enhancing agents at room temperature on the solubility of paracetamol. Different solubility enhancing agents like β-cyclodextrin, Hydroxypropyl-β- cyclodextrin, mannitol, urea and Sodium Lauryl Sulphate (SLS) in various concentrations like 0.25 % w/v, 0.5 % w/v, 0.75 % w/v and 1.0 % w/v were used to study the solubility of paracetamol in water as well as phosphate buffer pH 7.4 system.
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