scRepertoire 2 Full Data
Authors/Creators
-
1.
Washington University in St. Louis
Description
This object contains T cells from bronchoalveolar lavage fluid and peripheral blood samples collected from four patients with severe COVID-19-associated acute respiratory distress syndrome (ARDS). The data is compatible with contig_list and paired TCR sequencing information can be integrated using combineExpression. The original study by Zhao et al. identified clonally expanded tissue-resident memory-like Th17 cells (Trm17 cells) in the lungs of severe COVID-19 patients, characterized by expression of IL-17A and GM-CSF, which may contribute to pulmonary hyperinflammation. For full details on the experimental design and findings, see Zhao et al. (2021) Science Immunology.
Full visualizations for the cohort are seen at: https://www.borch.dev/uploads/screpertoire/
Files
Files
(251.6 MB)
| Name | Size | Download all |
|---|---|---|
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md5:393ae8b9dbf955ed7f47f89fb76baca3
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251.6 MB | Download |
Additional details
Dates
- Available
-
2026-01-08
Software
- Repository URL
- https://github.com/BorchLab/scRepertoire
- Programming language
- R
References
- Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LU. Clonal expansion and activation of tissue-resident memory-like TH17 cells expressing GM-CSF in the lungs of patients with severe COVID-19. Science immunology. 2021 Feb 23;6(56):eabf6692.