Intraoperative Neuropixels Tool Suite

This Zenodo deposit provides an open, academic-use only release of a custom surgical toolset developed to support human intracortical recordings using Neuropixels-NHP probes. The toolset was designed to integrate seamlessly into existing neurosurgical workflows, with a particular focus on precision, sterility, and compatibility with standard stereotactic frames and operating room practices.

The disclosure includes engineering drawings and 3D design files for the following components:

·       Probeholder: A reusable, sterilizable holder that centers the Neuropixels probe along its axis, incorporates an anti-rotation channel, and provides millimeter-scale depth markings to enable controlled advancement during neurosurgical implantation.

·       Stop Cap: A depth-limiting accessory that ensures consistent insertion depth and mitigates risk of over-advancement.

·       Reducing Block: An interface component designed to align and stabilize the probeholder within the either a stereotactic frame or neurosurgical robot workflow.

·       Sterile Straw: A simple, low-profile sterile interface that preserves sterility of the headstage and probe cabling while maintaining compatibility with the surgical approach.

Accompanying this disclosure are the complete engineering drawings, as well as .stl and .step files for each component, enabling fabrication, modification, and adaptation by academic groups. These materials are provided to facilitate reproducibility, encourage method-sharing within the research community, and support ongoing development of safe and reliable clinical neuroscience tools. Tools should be printed using either a Form3B or Form 4B Medical printer using sterilizable rigid resin.

The publication of this toolset is coordinated with a scientific manuscript that will be submitted for peer review in the near future, which provides a detailed description of the design rationale, fabrication methodology, testing procedures, and integration into the clinical workflow. This Zenodo release ensures that the underlying tools are accessible to the community at the time of manuscript submission.