PLATELET-RICH FIBRIN (L-PRF), TREATMENT OPTION FOR CLOSING OROANTRAL COMMUNICATION IN AN ONCOLOGIC PATIENT: A REVIEW AND CASE REPORT

Leukocyte and Platelet Rich Fibrin(LPRF) is an autologous biomaterial used in grafting procedures. It consists of a fibrin matrix enriched with leukocytes, platelets, leukocyte-derived cytokines, and growth factors, all obtained from a simple blood sample. This case report aims to present the clinical application of L-PRF in the treatment of oroantral communication in an oncology patient. A 59-year-old female patient undergoing chemotherapy presented with right maxillary sinusitis and a fractured maxillary first molar (tooth #3), which exhibited a periapical lesion in continuity with the maxillary sinus. The proposed treatment involved the extraction followed by closure of the resulting oroantral fistula. To minimize invasiveness, the treatment strategy focused on obliterating the communication between the oral cavity and the maxillary sinus by filling the extraction socket with an autologous L-PRF membrane. After four months of follow-up, the patient showed complete resolution of the maxillary and alveolar infection, with no evidence of persistent communication between the oral cavity and the sinus. The use of L-PRF resulted in satisfactory outcomes, including new bone formation and the prevention of maxillary osteonecrosis. This case demonstrates that L-PRF can be a viable and effective option for the management of oroantral communication,particularly in oncology patients where minimally invasive approaches are preferred.