Published October 30, 2025 | Version CC-BY-NC-ND 4.0
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Synthesis, Characterization, and Evaluation of the Antibacterial Activity of Some Novel Thiazolo- [1,2,4] Triazolo [1,5-a] Pyridine Derivatives

Creators

  • 1. Professor, Department of Chemistry, Sree Chaitanya College of Engineering, Karimnagar, Hyderabad (Telangana), India.

Contributors

  • 1. Professor, Department of Chemistry, Sree Chaitanya College of Engineering, Karimnagar, Hyderabad (Telangana), India.
  • 2. Assistant Professor, Department of Chemistry, Government Degree College for Women (Autonomous), Nalgonda, Hyderabad (Telangana), India.
  • 3. Assistant Professor, Department of Chemistry, Government Degree College, Ibrahimpatnam, Ranga Reddy, Hyderabad (Telangana), India.

Description

Abstract: A novel four-step scientific protocol has been reported for the synthesis of thiazolo- [1,2,4] triazolo[1,5-a] pyridine and its derivatives (6a-c) as target moieties in good overall yields by using 1-(2-(Trifluoromethyl)-5-methylthiazol-4- yl) ethanone (1) as starting compound. The IR, PMR, Mass spectral data, and elemental analysis validated the chemical structures of all the intermediates and products. Furthermore, the newly synthesised intermediates and final derivatives were screened for their antibacterial activity against different bacterial strains, and it was found that a few of them exhibited noteworthy antibacterial activity with varying degrees of disparity.

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Additional details

Identifiers

DOI
10.54105/ijac.B2030.05021025
EISSN
2582-8975

Dates

Accepted
2025-10-15
Manuscript received on 02 May 2025 | First Revised Manuscript received on 19 May 2025 | Second Revised Manuscript received on 16 September 2025 | Manuscript Accepted on 15 October 2025 | Manuscript published on 30 October 2025.

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