Published October 28, 2025
| Version v1
Dataset
Open
Epithelial-mesenchymal cell competition coordinates fate transitions across tissue compartments during lung development and fibrosis
Description
10x multiome data on E15.5 and E18.5 mouse lungs from ctrl, Tbx4-rtTa;Tet-Cre;Snai1f/f;Snai2f/f, Tbx4-rtTa;Tet-Cre;Yap1f/f;Wwtr1f/f and Tbx4-rtTa;Tet-Cre;Stk3f/f;Stk4f/f (Mst12) mice induced from E9.5 onwards.
10x flex data on mouse lungs from CTRL non injured, CTRL 6 weeks after bleo injury, Plin2-CreERT2;Yap1f/f;Wwtr1f/f 6 weeks after bleo injury and Acta2-CreERT2;Snai1f/f;Snai2f/f mice 6 weeks after bleomycin injury treated with tamoxifen starting at 2 weeks post injury
Files
Files
(716.6 MB)
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Additional details
Funding
- National Institutes of Health
- Cell competition in pulmonary fibrosis and ARDS R35HL161169