Published October 22, 2025
| Version v1
Dataset
Open
Data for Enantioselective Synthesis of 3-Alkyl-1,5-Functionalized-1,4-Diynes via Isoxazol-5(4H)-ones
Creators
-
1.
Universitat de València
- 2. Universitat de València Facultat de Química
Description
A one-pot enantioselective strategy has been developed for the synthesis of chiral 3-alkyl-1,5-functionalized-1,4-diynes. The key step involves an organocatalytic enantioselective conjugate addition of isoxazol-5(4H)-ones to nitroenynes, affording highly enantioenriched intermediates in good yields. Subsequent Zard-type transformation under one-pot conditions enabled the preparation of chiral skipped diynes with good overall yields and excellent enantioselectivities. This study highlights the synthetic versatility of the isoxazol-5(4H)-one scaffold and its value as a platform for accessing structurally diverse and synthetically relevant building blocks.
Files
Compound_3aa.zip
Files
(18.7 MB)
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Additional details
Funding
- Agencia Estatal de Investigación
- PID2023-147402NB-100
- Agencia Estatal de Investigación
- PID2020-116944GB-100