Published October 31, 2025 | Version v1
Journal article Open

BRUGADA TIPO I EN PACIENTE ESTABLE: REPORTE DE CASO

  • 1. Universidad Libre Seccional Cali, Santiago de Cali, Colombia
  • 2. Clínica Cali, Santiago de Cali, Colombia
  • 3. clínica nuestra señora de los remedios, Santiago de Cali, Colombia

Description

El síndrome de Brugada es una canalopatía hereditaria de alta relevancia clínica, asociada con arritmias ventriculares potencialmente letales y muerte súbita. Desde su primera descripción en 1992, esta condición ha evolucionado y se diagnostica mediante un patrón electrocardiográfico característico en las derivaciones precordiales derechas. El objetivo de este reporte de caso es describir el manejo integral de un paciente estable de 59 años con patrón de Brugada tipo I, enfatizando la importancia de una evaluación temprana y el uso de estrategias terapéuticas basadas en la evidencia. Se realizó una revisión de la literatura utilizando bases de datos como PubMed, centrándose en estudios recientes sobre la patogenia, estratificación del riesgo y tratamiento del síndrome. Los principales hallazgos incluyen la detección del patrón de Brugada tipo I en el EKG, la confirmación diagnóstica mediante un estudio electrofisiológico percutáneo que evidenció la inducibilidad de arritmias, y la implantación de un desfibrilador cardioversor implantable bicameral como medida preventiva definitiva. Se concluye que la detección oportuna y el manejo adecuado, con la colaboración estrecha entre urgenciólogos, cardiólogos y electrofisiólogos, son esenciales para reducir el riesgo de eventos arrítmicos mayores y mejorar la supervivencia de los pacientes afectados.

Abstract (English)

Brugada syndrome is a hereditary channelopathy of high clinical significance, associated with potentially lethal ventricular arrhythmias and sudden cardiac death. Since its initial description in 1992, this condition has evolved and is now diagnosed based on a characteristic electrocardiographic pattern in the right precordial leads. The objective of this case report is to describe the comprehensive management of a stable 59-year-old patient presenting with a Brugada type I pattern, emphasizing the importance of early evaluation and the implementation of evidence-based therapeutic strategies. A literature review was conducted using databases such as PubMed, focusing on recent studies addressing the pathogenesis, risk stratification, and treatment of Brugada syndrome. The principal findings include the detection of the Brugada type I pattern on the electrocardiogram (ECG), diagnostic confirmation through a percutaneous electrophysiological study (EPS) that demonstrated arrhythmia inducibility, and the subsequent implantation of a dual-chamber implantable cardioverter-defibrillator (ICD) as a definitive preventive measure. In conclusion, timely detection and appropriate management—facilitated by close collaboration among emergency physicians, cardiologists, and electrophysiologists—are essential to reduce the risk of major arrhythmic events and improve patient survival.

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Additional details

Additional titles

Translated title (English)
BRUGADA TYPE I IN A STABLE PATIENT: A CASE REPORT

Identifiers

ISSN
2530-5468

Dates

Submitted
2025-08-25
Accepted
2025-10-03

Software

References

  • 1. El Sayed M, Goyal A, Callahan AL. Brugada Syndrome. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK519568/ 2. Conte G, DE Asmundis C, Sieira J, Levinstein M, Chierchia GB, DI Giovanni G, Baltogiannis G, Ciconte G, Saitoh Y, Casado-Arroyo R, Pappaert G, Brugada P. Clinical characteristics, management, and prognosis of elderly patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2014 May;25(5):514-519. doi: 10.1111/jce.12359. Epub 2014 Jan 21. PMID: 24400668. 3. Eckardt, L., Veltmann, C. More than 30 years of Brugada syndrome: a critical appraisal of achievements and open issues. Herzschr Elektrophys 35, 9–18 (2024). https://doi.org/10.1007/s00399-023-00983-y 4. Li KHC, Lee S, Yin C, Liu T, Ngarmukos T, Conte G, Yan GX, Sy RW, Letsas KP, Tse G. Brugada syndrome: A comprehensive review of pathophysiological mechanisms and risk stratification strategies. Int J Cardiol Heart Vasc. 2020 Jan 21;26:100468. doi: 10.1016/j.ijcha.2020.100468. Erratum in: Int J Cardiol Heart Vasc. 2020 Dec 19;32:100699. doi: 10.1016/j.ijcha.2020.100699. PMID: 31993492; PMCID: PMC6974766. 5. Santoro, F., Di Biase, L., Curcio, A. et al. Psychological profile of patients with Brugada syndrome and the impact of its diagnosis and management. npj Cardiovasc Health 2, 3 (2025). https://doi.org/10.1038/s44325-024-00042-6 6. Iqbal M, Putra ICS, Pranata R, Budiarso MN, Pramudyo M, Goenawan H, Akbar MR, Kartasasmita AS. Electrocardiographic Markers Indicating Right Ventricular Outflow Tract Conduction Delay as a Predictor of Major Arrhythmic Events in Patients With Brugada Syndrome: A Systematic Review and Meta-Analysis. Front Cardiovasc Med. 2022 Jun 17;9:931622. doi: 10.3389/fcvm.2022.931622. PMID: 35783830; PMCID: PMC9247269. 7. Iqbal M, Putra ICS, Pranata R, Budiarso MN, Pramudyo M, Goenawan H, Akbar MR, Kartasasmita AS. Electrocardiographic Markers Indicating Right Ventricular Outflow Tract Conduction Delay as a Predictor of Major Arrhythmic Events in Patients With Brugada Syndrome: A Systematic Review and Meta-Analysis. Front Cardiovasc Med. 2022 Jun 17;9:931622. doi: 10.3389/fcvm.2022.931622. PMID: 35783830; PMCID: PMC9247269. 8. Tse G, Liu T, Li KH, Laxton V, Chan YW, Keung W, Li RA, Yan BP. Electrophysiological Mechanisms of Brugada Syndrome: Insights from Pre-clinical and Clinical Studies. Front Physiol. 2016 Oct 18;7:467. doi: 10.3389/fphys.2016.00467. PMID: 27803673; PMCID: PMC5067537.