Formulation And Evaluation of Orphenadrine Nanogel

Nanogels have emerged as advanced drug delivery systems owing to their high water content, biocompatibility, and ability to provide controlled release. The present study was designed to investigate the potential of nanogel formulations for enhancing the topical delivery of Orphenadrine, a centrally acting muscle relaxant. Nanoparticles were first prepared using the solvent evaporation method, where Eudragit S100 served as the polymer, and surfactants (SPAN 80 and TWEEN 80) were employed to stabilize the formulations. Carbopol 940 and HPMC were incorporated as gelling agents to form nanogels at different concentrations. The effect of surfactant type on nanoparticle characteristics and the influence of polymeric gel bases on drug release were systematically evaluated. The prepared formulations were characterized for particle size, polydispersity index, zeta potential, viscosity, spreadability, and in vitro diffusion. The results confirmed acceptable nanoscale particle size, and stable zeta potential values. In vitro drug release studies demonstrated that certain formulations achieved rapid release, while others exhibited sustained release patterns, depending on the type and concentration of gelling agent. Overall, the study highlights that Orphenadrine-loaded nanogels based on Carbopol 940 and HPMC provide stable physical attributes, good spreadability, and desirable release behavior, suggesting their potential as effective carriers for topical drug delivery.