A Mitochondrial Basis for Casein-Induced Inflammation: Haplogroups J & K Susceptibility to BCM‑7

This white paper introduces the Queen Hypothesis, a novel theory proposing that individuals with mitochondrial haplogroups J and K are uniquely sensitive to BCM‑7, an inflammatory peptide released during digestion of A1 dairy. Drawing from mitochondrial genetics, nutritional science, and peptide biochemistry, the paper explains how this sensitivity may lead to a chronic condition termed Wrong Milk Syndrome. The author presents theoretical modeling for the Inflammation Drop Point, a 21-day clearance window tied to symptom relief. With over 200 million people worldwide potentially affected, this hypothesis offers a new framework for personalized dietary guidance and mitochondrial-informed public health strategies.

This record (Version 3) supersedes Version 2, available at https://doi.org/10.5281/zenodo.16213366