A mitochondrial basis for casein-induced inflammation: haplogroups J and K susceptibility to β-casomorphin-7

This white paper presents Version 5 of the Queen Hypothesis, a theory proposing that individuals with mitochondrial haplogroups J and K are uniquely sensitive to β-casomorphin-7 (BCM-7), an inflammatory peptide released during the digestion of A1 dairy. Drawing from mitochondrial genetics, nutritional science, and peptide biochemistry, the paper explains how this sensitivity may lead to a chronic condition termed Wrong Milk Syndrome.

Version 5 incorporates corrected and verified references, clarifies prior citations, and refines the theoretical framework for the Inflammation Drop Point, a clearance window tied to symptom relief. The hypothesis offers a testable model for personalized dietary guidance and mitochondria-informed public health strategies.