Proteomic insights into mental health status: plasma markers in young adults
Authors/Creators
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1.
University of Eastern Finland
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2.
Institute for Molecular Medicine Finland
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3.
University of Helsinki
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4.
University of Jyväskylä
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5.
Indiana University Bloomington
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6.
National Institute for Public Health and the Environment
Description
Global emphasis on enhancing prevention and treatment strategies necessitates an increased understanding of the biological mechanisms of psychopathology. Plasma proteomics is a powerful tool that has been applied in the context of specific mental disorders for biomarker identification. The p-factor, also known as the “general psychopathology factor”, is a concept in psychopathology suggesting that there is a common underlying factor that contributes to the development of various forms of mental disorders. It has been proposed that the p-factor can be used to understand the overall mental health status of an individual. Here, we aimed to discover plasma proteins associated with the p-factor in 775 young adults in the FinnTwin12 cohort. Using liquid chromatography–tandem mass spectrometry, 13 proteins with a significant connection with the p-factor were identified, 8 of which were linked to epidermal growth factor receptor (EGFR) signaling. This exploratory study provides new insight into biological alterations associated with mental health status in young adults.
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Additional details
Funding
Dates
- Available
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2024-01-24