HP Study Initiation Package, including study protocol

In the context of global health, chronic infections such as Helicobacter Pylori (HP) significantly contribute to the gastric cancer burden. Addressing this, WP2 strategically focuses on integrating HP screening and eradication within occupational health surveillance programs. This integration serves as a primary preventive approach against gastric cancer, targeting both workers and their household members. The initiative is designed to evaluate the effectiveness and cost-efficiency of HP prevention in occupational health settings, while also investigating the prevalence and determinants of HP infection across various worker cohorts. A key aspect of WP2 is the promotion of awareness about HP-related diseases and the importance of prevention strategies. Furthermore, the project aims to develop and coordinate comprehensive plans for large-scale implementation of HP prevention, drawing insights from the results of pilot projects.

The methodology of WP2 encompasses a range of tasks, including the design of screening and eradication protocols, coordination of pilot projects, and extensive data collection and analysis. This is coupled with developing strategies for broad implementation within the occupational health surveillance framework. Diagnostic and treatment strategies primarily involve serology and stool antigen tests to identify HP infections. Positive cases are referred for treatment, and family members are also considered for referral and management by the healthcare system of every country. Data management is a critical component, involving the collection, harmonization, and analysis of data to evaluate the intervention's determinants and effectiveness, including monitoring treatment compliance and success in eradication.

The expected impact of WP2 is multifaceted. Occupational health-based screenings are projected to enhance participation rates, particularly among workers with unconventional working hours. The 'screen and treat' strategy has the potential to be a cost-effective approach that may help, reduce the prevalence of HP and consequently, the associated gastric complications and cancer risks. This intervention aligns with the 'Total Worker Health' concept, utilizing occupational health visits as opportunities for broader health promotion and disease prevention. In conclusion, WP2 is a comprehensive effort targeting a significant public health concern by embedding HP screening and eradication into the existing occupational health surveillance frameworks. This innovative approach aims at gastric cancer prevention and enhancing overall worker health and well-being. The model established by WP2 has the potential to be replicated in diverse settings and populations, potentially setting a precedent for similar health initiatives within occupational health programs. The success of WP2 could thus open pathways for addressing other health issues through occupational health surveillance.

The intended audience of this deliverable consists of members of the CPW consortium and the European Commission.