Published May 31, 2025 | Version 1
Project deliverable Open

D2.5_Online web tool for performing HMM searches

  • 1. ROR icon Universität Hamburg
  • 2. ICREA -Institucio Catalana de Recerca i Estudis Avançats
  • 3. ROR icon Barcelona Supercomputing Center
  • 4. ROR icon Instituto de Catálisis y Petroleoquímica
  • 5. Institute of Catalysis - CSIC

Description

This deliverable introduces AHATool, an automated, user-friendly platform for advanced protein sequence screening using profile Hidden Markov Models (HMMs). Originally developed as a command-line pipeline, AHATool was packaged as a Docker container and integrated into the Horus workflow manager by BSC for 
improved accessibility and ease of use. 
AHATool allows researchers to analyze both public and private datasets, detecting remote homologs with high sensitivity and leveraging comprehensive resources like Pfam/InterPro. Within Horus, users can easily upload input files, select databases, and adjust key parameters through an intuitive web interface, seamlessly 
integrating sequence screening into broader bioinformatics workflows. 
No significant deviations from the original plan occurred, aside from its integration in Horus, which enhances stability and usability. AHATool in Horus now provides the scientific community with a robust, scalable, and efficient solution for protein annotation and discovery. 

Files

FE_UHAM_D2.5_Online web tool for performing HMM searches_v1.pdf

Files (647.8 kB)

Additional details

Funding

European Commission
FuturEnzyme - Technologies of the Future for Low-Cost Enzymes for Environment-Friendly Products 101000327
European Commission
OXIPRO - Transition towards environment-friendly consumer products by co-creation of an oxidoreductase foundry 101000607