Temporal Biomarker Discovery via Vitamin D Nuclear Receptor clearance and Observational Mucosal Pattern Cycling: Hypothesis and Preliminary Observations.

This white paper presents a novel hypothesis proposing that microbial byproducts may obstruct the activation of Vitamin D nuclear receptors (VDRs), leading to suppressed gene expression across multiple physiological systems. The concept of "layered pathogenic interference" suggests that clearance occurs in a sequential, system-by-system manner — restoring VDR function and gene expression layer by layer.

Under a defined protocol combining rosemary oil (carnosic acid) and targeted probiotic strains, the author has documented highly reproducible geometric tongue patterns cycling every 24–36 hours — patterns which appear to reflect active immune clearance processes.

The first system reset observed was full restoration of olfactory function (after years of anosmia) within 10 days of initiating the protocol, coinciding with the initial emergence of tongue patterns.

These findings suggest the identification of a potential new temporal biomarker of immune activity — distinct from circadian rhythms — with possible applications in monitoring immune clearance, chronic disease management, and VDR-related therapeutic interventions.

The author has filed a provisional patent with the USPTO protecting this discovery, and is now actively seeking scientific collaborators and funding to validate and further develop this hypothesis through laboratory and clinical research.