Long-Term Effects of Neural Therapy in Fibromyalgia – A Retrospective Multicenter Analysis Effectiveness of Neural Therapy in Patients with Fibromyalgia

Background: Fibromyalgia syndrome (FMS) is a chronic pain condition associated with widespread musculoskeletal
discomfort, persistent fatigue, and diminished quality of life. Many patients show limited response to conventional treatments.
Neural therapy (NT), a core modality of regulatory medicine, aims to restore autonomic balance and modulate inflammatory
reflexes through targeted injections of local anesthetics.
Objective: This retrospective multicenter study evaluates the long-term effectiveness of NT in 565 patients with treatment-
resistant fibromyalgia who previously failed to respond adequately to standard therapies.
Methods: Data were collected from five neural therapy clinics between 2017 and 2024. Standardized outcome measures were
assessed at baseline, immediately post-treatment, and at 3, 6, and 12 months:
• Pain intensity: Visual Analog Scale (VAS)
• Disease burden: Fibromyalgia Impact Questionnaire (FIQ)
• Quality of life: Short Form-36 (SF-36), including subdomains (physical function, pain, energy/fatique, social function,
general health perception)
Statistical analysis employed the Friedman test for repeated measures.
Results:
• VAS scores dropped from a mean of 8.5 to 1.9 post-treatment and remained below 3.0 over 12 months.
• FIQ scores decreased from a baseline mean of 78.1 to 18.6 and remained significantly improved (mean 24.9 at 12
months).
• SF-36 physical function increased from 33.5 to 82.0, with sustained gains at all follow-ups.
• Social functioning, general health perception, pain and vitality domains showed similar sustained improvements.
• The treatment completion rate was 92.9%, indicating high tolerability and patient satisfaction.
Conclusion: Neural therapy produced significant and sustained improvements in pain, physical functioning, energy, and social
participation in fibromyalgia patients. Its multimodal effects—autonomic modulation, anti-inflammatory action, and improved
microcirculation—support its use in integrative and regulatory pain medicine. This study presents strong evidence for neural
therapy as an effective, safe, and cost-efficient option in patients with resistant fibromyalgia.
Further randomized controlled trials are needed to confirm these findings and establish standard treatment protocols