Formulation and Evaluation of Herbal Rectal Suppositories Containing A Flax Seed Extract (Cocoa Butter Based)

The formulation and evaluation of herbal rectal suppositories containing flaxseed extract is an Innovative approach in the development of natural and effective therapeutic systems. Flaxseed (Linum usitatissimum) is widely known for its pharmacological properties, including anti-inflammatory, antioxidant, and laxative effects, attributed to its high content of Lignans, omega-3 fatty acids, and mucilage. This study aimed to develop a rectal delivery System utilizing flaxseed extract to address conditions such as constipation, inflammation, And local discomfort in the rectal region. In order to prevent its reported gastrointestinal Irritation and to give children a quick onset of effect, the current study set out to develop and Assess rectal suppositories containing flex seed extract as a new dosage form. Glycerol Gelation was used as the suppository basis to make suppositories in a variety of formulations. The physical characteristics of the produced suppositories, weight variation, drug content, Melting point, fracture point, and disintegration time hardness test were examined. According To the results, different concentrations of the glycerol-gelatin base were utilised with Increasing drug concentrations, and the outcomes with their standard parameters varied. Out Of the six formulas presented, F3 demonstrated the best formulation.