Published May 7, 2025
| Version v1
Dataset
Open
Database Calibrated Assessment Process (DCAP) Data Release Using ToxValDB v9.6.1
Creators
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Harrill, Alison H.
(Project leader)1
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Hagiwara, Shintaro
(Project member)2
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Weitekamp, Chelsea A.
(Project member)1
- Stanish, Paul C. (Project member)2
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Wall, Jonathan T.
(Project member)1
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Sayre, Risa R.
(Project member)1
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Davidson-Fritz, Sarah E.
(Project member)1
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Vitense, Kelsey
(Project member)1
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Chang, Daniel T.
(Project member)1
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Devito, Michael J.
(Project member)1
- Gonzales, Chris J. (Project member)1
- Groover, Maxwell (Project member)1
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Hughes, Michael F.
(Project member)1
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Judson, Richard S.
(Project member)1
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Lambert, Jason C.
(Project member)1
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Lowe, Charles N.
(Project member)1
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Mutlu, Esra
(Project member)1
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Paul Friedman, Katie
(Project member)1
- Watkins, Andrew M. (Project member)1
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Williams, Antony J.
(Project member)1
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Krewski, Daniel
(Project leader)2
- Paoli, Greg M. (Project leader)2
-
Thomas, Russell S.
(Project leader)1
- 1. U.S. EPA
- 2. Risk Sciences International (RSI)
Description
This dataset contains files related to the EPA Database Calibrated Assesment Process (DCAP) using data exported and processed from the Toxicity Values DB v9.6.1. Data included comprise: (1) The export workflow on ToxValDB v9.6.1 data, filtered to chemicals with five or more study groups, and a document catalog for all documents associated with included records; (2) The summary results of the DCAP on the calibration chemical set and on 1,001 DCAP-eligible chemicals, inclusive of uncertainties and the calibrated toxicity value (CTV) as provided in a table; and (3) Expanded pdf reports detailing input data and DCAP results for each of the chemicals evaluated using DCAP.
The US Environmental Protection Agency (EPA) and other regulatory agencies routinely assess whether certain chemical exposures can result in harmful health effects. Traditional human health assessments rely upon expert judgement of dose-effect linkages observed in animal toxicology or human studies. Because both the collection of toxicology data and the synthesis of the information can take multiple years to complete, there are relatively few available assessments for decision making. Identifying methods that yield significant time and resource efficiencies to the process will have scalable public health benefits. To address the need, EPA developed a methods-based approach to generate oral, non-cancer human health assessments that builds on previously published approaches and guidance. The approach uses the EPA-managed Toxicity Values Database (ToxValDB) that contains dose response summary values (DRSVs) from in vivo toxicity studies. The DRSVs are converted to an oral, chronic, human equivalent dose using a series of standard conversion factors. A point-of-departure (POD) can then be calculated across a distribution of studies for a given chemical using a calibration percentile that is benchmarked to critical effect POD(s) from published human health assessments. Traditional and process specific uncertainties are incorporated to derive a calibrated toxicity value (CTV), defined as an estimate of a daily oral dose to the human population that is likely to be without appreciable risk of adverse non-cancer health effects over a lifetime.
Files
DCAP ToxValDB v9.6.1.zip
Files
(1.2 GB)
| Name | Size | Download all |
|---|---|---|
|
md5:5f4c6e5269e934074c58354649c59506
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1.2 GB | Preview Download |
Additional details
Software
- Repository URL
- https://github.com/USEPA/toxvaldb_dcap_prep
- Programming language
- R
- Development Status
- Active