Re-examining the Controversial Case of 'Autistic Enterocolitis': The Role of Gut-Brain Axis in Autism Spectrum Disorder

This paper re-examines autistic enterocolitis (AuEC) which the authors believe is crucial due to its implications for understanding and managing autism spectrum disorder (ASD) and associated gastrointestinal (GI) symptoms. Despite its controversial origin, with the discredited 1998 study of Wakefield et al., many individuals with ASD experience significant GI issues - abdominal pain, diarrhea, and constipation - that affect their quality of life. Emerging research on the Gut-Brain Axis suggests potential biological links between ASD and GI dysfunction, including differences in gut microbiota, immune responses, and the heritable traits of gut microbiome. The aim of this paper is to revisit the concept of AuEC with evidence-based studies to make constructive sense of the controversy, leading to more holistic treatment approaches that address both behavioral and GI symptoms. By objectively investigating AuEC, authors hope to advance knowledge and improve care for those with ASD.