AMENAMEVIR: A BREAKTHROUGH IN HERPESVIRUS THERAPY
- 1. MD, Senior Resident, Department of Dermatology, Andaman and Nicobar Islands Institute of Medical Sciences, Port Blair.
- 2. MD, Assistant Professor, Department of Skin and VD, Government Medical College , Orai.
- 3. MBBS, Department of Dermatology, Andaman and Nicobar Islands Institute of Medical Sciences, Port Blair.
- 4. MD, Senior Resident, Department of DVL, Tagore Medical College and Hospital, Chennai.
Description
Amenamevir is a promising antiviral agent with strong activity against herpes simplex virus (HSV) and varicella-zoster virus (VZV). This review article aims to explore its pharmacodynamics, therapeutic potential, and safety profile in detail. Amenamevir functions by inhibiting the viral helicase-primase complex, a crucial step in viral DNA replication, distinguishing it from other antiviral drugs. The article examines the results from clinical trials assessing its efficacy in treating recurrent herpesvirus infections, its pharmacokinetic properties, and its suitability for patients with compromised immune systems. We also discuss the drugs safety and tolerability, identifying common side effects, drug interactions, and contraindications. Furthermore, the review highlights Amenamevirs potential role in managing antiviral resistance and its possible broader applications in the treatment of chronic viral infections. Finally, future directions are outlined, including the exploration of combination therapy and the development of more accessible oral formulations, to optimize the clinical use of Amenamevir.
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