Published March 8, 2025 | Version v1
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COMPARATIVE STUDY OF THE ANTIBACTERIAL ACTIVITY OF ROOTS, BARKS AND LEAVES OF JATROPHA MULTIFIDA, JATROPHA CURCAS AND ZANTHOXYLUM ZANTHOXYLOIDES

  • 1. Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Laboratory Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Benin.
  • 2. Department of Continuing Education, National Medical and Health Institute, University of Abomey-Calavi, Benin.

Description

Antimicrobial resistance is a major public health issue. This study compares the antibacterial activity of leaves, bark, and roots of Jatropha curcasJatropha multifida, and Zanthoxylum zanthoxyloides. Extracts (water, ethanolic, and hydro-ethanolic) were tested against Staphylococcus aureus and Klebsiella pneumoniae, and their antioxidant activity was assessed using the DPPH test. Polyphenol and flavonoid levels were quantified spectrophotometrically.Hydro-ethanolic extracts of J. multifida bark and Z. zanthoxyloides leaves showed strong activity against K. pneumoniae (MIC, MBC: 6.25mg for J. curcasJ. multifida 3.12mg for Z. zanthoxyloides). Against S. aureus, the best were J. curcasJ.multifida (3.12mg), and Zzanthoxyloides(1.5mg). Leaves and bark were richer in flavonoids and polyphenols (p=0.001) and exhibited superior antioxidant activity. Using leaves and bark over roots enhances sustainability.

 

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