Effectiveness and safety of three Antivirals in the Treatment of Severe Manifestations of Monkeypox in Humans. An Approach

Monkeypox or “Mpox”, is a zoonosis caused by the monkeypox virus, a double-stranded DNA virus, belonging to the genus Orthopoxvirus, of the family Poxviridae. There are two main clades of the virus, both endemic in Africa: clade I, associated with the Congo Basin, and clade IIa, related to West Africa. In 2022, a global clade IIb outbreak led the WHO to declare a health emergency, lifted in May 2023. However, in August 2024, the emergency was reactivated due to a resurgence of the disease in Africa, linked to a new strain of clade Ib, which is predominantly transmitted sexually.