ABCA3 functions in multi-drug resistance in human cancer.

We describe here a function for the ATP-binding cassette gene ABCA3 in multi-drug resistance in human cancer (1-3), supported by evidence by demonstrating its transcriptional up-regulation with significance at the transcriptome level in metastasis to distant organ sites in human breast cancer (4, 5), and by separate evidence demonstrating that ATP-binding cassette genes function in multi-drug resistance: in resistance to a platinum agent, in resistance to doxorubicin, and in resistance to paclitaxel (2).