Extracellular matrix change in patients with various forms of atrial fibrillation

Goryachiy A. V., Gozhenko A. I., Karpenko Yu. I., Levchenko E. M., Goryachiy V. V., Kuznetsova M. A., Arapu M. I. Extracellular matrix change in patients with various forms of atrial fibrillation. Journal of Education, Health and Sport. 2017;7(6):1223-1235. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1472947

http://ojs.ukw.edu.pl/index.php/johs/article/view/6232

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1223 Journal of Education, Health and Sport eISSN 2391-8306 7

© The Author  2017;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 03.06.2017. Revised: 20.06.2017. Accepted: 30.06.2017.

EXTRACELLULAR MATRIX CHANGE IN PATIENTS WITH VARIOUS FORMS OF ATRIAL FIBRILLATION

A. V. Goryachiy, A. I. Gozhenko, Yu. I. Karpenko, E. M. Levchenko, V. V. Goryachiy,

M. A. Kuznetsova, M. I. Arapu

Ukrainian Research Institute of Transport Medicine,

Odessa Regional Clinical Hospital

Abstract

Purpose: We studied the change in serum collagen markers in patients with various forms of atrial fibrillation (AF)

Methods: Collagen type C-terminal propeptide (CTPK-I), C-terminal telopeptide of type I collagen (CTTK-I), matrix metalloproteinase I, and tissue inhibitors of matrix metalloproteinase I were used as markers for collagen synthesis. The study group comprised - 70 people, control - 20.

Results: The level of CTCP-I and CTTP-I in patients with AF was significantly higher in comparison with the control group (91 +27 ng / ml, 67 + 11 ng / ml, p <0.001 and 0.38 + 0.20 ng / ml, 0.25 +0.08 ng / ml, p <0.001, respectively). The level of TSCP-I in patients with persistent and chronic AF was significantly higher (105 +28 ng / ml and 126 + 26 ng / ml vs. 80 +21 ng / ml, p <0.001) compared with patients with paroxysmal AF. A significantly lower level of matrix metalloproteinase-1 (MMP-1) was observed in patients with persistent and chronic forms of AF, but the level of tissue inhibitor of matrix metalloproteinase-1 (TIMMP-1) was increased in comparison with patients with paroxysmal AF (09.67 + 4.41 ng / Ml, 11.90 + 4.79 ng / ml vs. 14.98 + 6.28 ng / ml, p = 0.03 and 187 + 49 ng / ml, 155 + 45 ng / ml vs. 130 + 38 ng / ml, p <0.001, respectively). The level of TIMMP-1 was significantly lower in the control group compared with patients with paroxysmal and persistent and chronic forms of AF (102 + 15 ng / ml, 130 +38 ng / ml, 155 + 45 ng / ml and 194 + 49 ng / ml , Respectively, p <0.001).

Conclusions: The serum level of type I collagen markers differs significantly between healthy people and patients with AF. Moreover, these markers also differ depending on AF form. It can be assumed that the intensity of extracellular synthesis and degradation of type I collagen can be related to the severity and type of AF.

Key words: serum collagen markers, atrial fibrillation, catheter ablation.