ANGIE - MAgnetically steerable wireless Nanodevices for the tarGeted delivery of therapeutIc agents in any vascular rEgion of the body

Part of EU Open Research Repository
Published January 20, 2025 | Version v1
Publication Open

Clinically Ready Magnetic Microrobots for Targeted Therapies

Creators

  • 1. Multi-scale Robotics Laboratory, ETH. Zurich
  • 2. Multi-scale Robotics Laboratory, ETH. Zurich, Magnebotix AG, Zurich, Switzerland
  • 3. Multi-scale Robotics Laboratory, ETH
  • 4. Multi-scale Robotics Laboratory, ETH. Zurich, Magnebotix AG, Zurich
  • 5. FAME Laboratory, University of Thessaly
  • 6. Departament de Ciència dels Materials i Química Física, Institut de Química Teòrica i Computacional, University of Barcelona
  • 7. Institute of Optoelectronics, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University
  • 8. Department of Obstetrics, University Hospital of Zurich, The Zurich Center for Fetal Diagnosis and Therapy, University of Zurich,
  • 9. Kantonsspital Aarau AG, Institut für Radiologie/ Abteilung für diagnostische und interventionelle Radiologie
  • 10. Center for Preclinical Development, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Description

Systemic drug administration often causes off-target effects limiting the efficacy of advanced therapies. Targeted drug delivery approaches increase local drug concentrations at the diseased site while minimizing systemic drug exposure. We present a magnetically guided microrobotic drug delivery system capable of precise navigation under physiological conditions. This platform integrates a clinical electromagnetic navigation system, a custom-designed release catheter, and a dissolvable capsule for accurate therapeutic delivery. In vitro tests showed precise navigation in human vasculature models, and in vivo experiments confirmed tracking under fluoroscopy and successful navigation in large animal models. The microrobot balances magnetic material concentration, contrast agent loading, and therapeutic drug capacity, enabling effective hosting of therapeutics despite the integration complexity of its components, offering a promising solution for precise targeted drug delivery.

Files

2501.11553v1.pdf

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Additional details

Funding

European Commission
ANGIE – MAgnetically steerable wireless Nanodevices for the tarGeted delivery of therapeutIc agents in any vascular rEgion of the body 952152

Software

Repository URL
https://arxiv.org/abs/2501.11553