Flow simulation of a collagen solution in syringes with different geometries

In recent years, cell therapy has emerged as a promising therapeutic strategy for many diseases, including Parkinson’s disease [1]. To increase cell viability, biomaterials are often used as scaffolds to facilitate cell deposition, through injection, to the site of interest. However, fluid forces acting on the cells during injection may lead to cell disruption or death [2]. This study aims to develop a novel device for the delivery of a cell-embedded collagen hydrogel, forming in situ. Here, we discuss computational results on constricted channels representing the connection between the syringe barrel and the needle to gain insight into the effect of syringe geometry.