Published January 3, 2025 | Version v3
Dataset Open

Supplementary Data for "Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance"

Authors/Creators

  • 1. Memorial Sloan Kettering Cancer Center
  • 2. ROR icon Centre for Genomic Regulation
  • 3. ROR icon Pompeu Fabra University

Description

We performed functional genomic profiling of diverse leukemias using label tracing techniques. We identified AML stem cell quiescence is defined by distinct promoter-centered chromatin and gene expression dynamics, and controlled by a novel transcription factor network, which is associated with disease persistence and chemotherapy resistance in multiple patients.

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