RESULTS OF PLACENTAL ORGANOMETRIC STUDY AND HISTOCHEMICAL STUDY OF COLLAGEN FIBERS IN CHORIOAMNIONITIS AND BASAL DECIDUITIS WITH CONCOMITANT IRON DEFICIENCY ANEMIA IN PREGNANT WOMEN

Ilika V. V., Davydenko I. S. RESULTS OF PLACENTAL ORGANOMETRIC STUDY AND HISTOCHEMICAL STUDY OF COLLAGEN FIBERS IN CHORIOAMNIONITIS AND BASAL DECIDUITIS WITH CONCOMITANT IRON DEFICIENCY ANEMIA IN PREGNANT WOMEN. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2018;3(80):109-116. ISSN 0049-6804.

DOI http://dx.doi.org/10.5281/zenodo.1450851

http://www.herald.com.ua

УДК 611-013.85:618.39-021.3

RESULTS OF PLACENTAL ORGANOMETRIC STUDY AND HISTOCHEMICAL STUDY OF COLLAGEN FIBERS IN CHORIOAMNIONITIS AND BASAL DECIDUITIS WITH CONCOMITANT IRON DEFICIENCY ANEMIA IN PREGNANT WOMEN

Ilika V. V., Davydenko I. S.

The State Institution of Higher Learning of Ukraine “Bukovina State Medical University”, Chernovtsy;

e-mail: vitaliy.ilika@bsmu.edu.ua.

Summary

Introduction. We failed to find any data as to the condition of the body’s stromal component in its connection with collagen fibers in the placenta under inflammation accompanied by iron deficiency anemia in pregnancy. The objective: to conduct organometric analysis of the placenta in chorioamnionitis and basal deciduitis accompanied by iron deficiency anemia in pregnanсy and determine the specific volume and optical density of collagen fibers of the chorionic and basal placental plate. 198 placentas were examined, histochemical method were used. The organometric analysis included determination of mass, thickness, volume and area of the maternal placental surface. Histochemical study of collagen fibers was carried out by N. Z. Slinchenko method in combination with computer-assisted microdensitometry. It has been revealed that in all forms of placental inflammation, with the exception of the area of its maternal surface, mass, thickness and volume of the organ increased. In case of comorbid anemia, all parameters remain within the limits of the placental indices of physiological pregnancy but are lower than those in inflamed placentas; optical density and specific volume of collagen fibers sharply decreased in case of acute chorioamnionitis and basal deciduitis, and in the case of chronicity they increase in comparison with the norm, while this was not regular in the studied layers of the placental chorionic plate. Comorbid iron deficiency anemia leads to an increase in these indices in all forms of placental inflammation.

Key words: inflammation of the placenta, iron deficiency anemia in pregnant women, collagen fibers.