Proteomics approach identifies aqueous humor biomarkers in retinal diseases
Description
This study explores proteins in aqueous humor to uncover molecular signatures and biomarkers for geographic atrophy (GA), a late form of age-related macular degeneration (AMD). Using an affinity-based proteomics approach, we compared non-AMD with GA AH, and identified 82 proteins significantly different in GA. Many of these proteins are expressed in the retina, especially the retinal pigment epithelium cells. Interestingly, analysis of AH from diabetic retinopathy patients revealed both shared and unique AH biomarkers with GA patients. SMOC2 and IL-6 emerged as distinct and strong potential GA biomarkers. This research shows that analyzing AH can help understand the pathophysiology of retinal diseases like GA and discover candidate biomarkers for disease progression.
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