Published September 13, 2018
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SYNTHESIS OF DIETHYL (2-BENZOYLAMINO-2-(PHENOXY) METHYL) PHOSPHONATE
- 1. *1Laboratory of Organic Chemistry, Faculty of Sciences Dhar El Mehraz, University Sidi Mohamed BenAbdellah, Fez, B.P.:1796-Fès Atlas, Morocco
Description
α-Amino esters possess a broad range of applications ranging from agro chemistry to medicine. We developed a simple, efficient, and environmentally benign method for the Synthesis of Diethyl (2-benzoylamino-2-(phenoxy) methyl) phosphonate by O-alkylation of diethyl (2-azido-2-benzoylaminomethyl) phosphonate with phenol. The structure of the newly synthesized compound was supported by 1H NMR, 13C-NMR and mass spectral data. This method has advantages of mild condition, no environmental pollution, and simple work-up procedures. Most importantly, the α-phosphonic aminoester was obtained in acceptable yields by this methodology.
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