Published October 8, 2024 | Version v1
Dataset Open

Autonomic Dysfunction Among Adult Survivors of Childhood Cancer in the St. Jude Lifetime Cohort Study

Creators

  • 1. ROR icon Brigham and Women's Hospital
  • 2. ROR icon St. Jude Children's Research Hospital
  • 3. ROR icon Baylor College of Medicine
  • 4. MD Anderson Cancer Center
  • 5. ROR icon University of Tennessee Health Science Center

Description

The dataset contains all variables of interest presented in the study. By downloading and using these data, you agree that you will cite the appropriate publication in any communications or publications arising directly or indirectly from these data; for utilization of data available prior to publication, you agree to respect the requested responsibilities of resource users under 2003 Fort Lauderdale principles; you agree that you will never attempt to identify any participant. 

When using downloaded data, please cite corresponding paper and this repository:

John D. Groarke MBBCh et al. (2024) Autonomic dysfunction among adult survivors of childhood cancer in the St. Jude Lifetime Cohort Study, JACC: CardioOncology. Available at: https://www.sciencedirect.com/science/article/pii/S2666087324002825 

Funding:

Support to St. Jude Children’s Research Hospital was provided by the National Cancer Institute grants U01 CA195547 (Drs Hudson and Ness) and R01 CA157838 (Dr Armstrong), the Cancer Center Support (CORE) grant P30 CA21765 (Dr C. Roberts), and the American Lebanese-Syrian Associated Charities (ALSAC). Dr Groarke has received research support from Amgen, Inc, was previously employed by Amgen, Inc; and is currently an employee of Pfizer. Dr Nohria has received research support from Bristol Myers Squibb; and consulting fees from AstraZeneca, Bantam Pharmaceuticals, Regeneron Pharmaceuticals, and Takeda Oncology. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Data dictionary:   

ID: Serial number
Abn_HR: Abnormal HR
BMI: BMI category
BMIadj: BMI adjusted
EF: Left ventricular ejection fraction
MVPA150: Moderate to Vigorous physical activity
PackYear: Pack years of smoking
Statin: Statin therapy
Studypop: Population
abpelGY: Abdominal/Pelvic radiation dose,Gy
acearb: ACE/AR inhibitors
agedx: Age at diagnosis
agegxt: Age at CPET
aldo: Aldosterone antagonists
alkyn: Alylating agent
amputation: Amputation
anthradose: Anthracycline dose mg/m2
apelvdose: Abdominal/pelvic dose
apelvrt: Abdominal/pelvic RT
asparyn: Aspariginase
avgee: E/e' ratio
badmtns: mtnstot 5+
betablock: Beta blockers
bleoyn: Bleomycin
bpblunt: Blunted blood presssure response
brainGY: Cranial radiation dose,Gy
brainrt: Brain RT
calcium: Calcium channel blockers
carboyn: Carboplatin
chestGY: Chest radiation dose,Gy
chestrt: Chest RT
ci: Chronotropic incompetence
cisyn: Cisplatin
dia: Diabetes mellitus
elevateRHR: Elevated HR
fev1: Forced expiratory volume in 1 second (FEV1) < 80% predicted
howmany: N of Markers of Autonomic Dysfunction
htn: Hypertension
late10: Lateral e’ <10 cm/sec
lip: Dyslipidemia
loop: Loop diuretics
male: Male
markers2: 2 or more markers of Autonomic Dysfunction
mtxyn: Methotrexate
nephrectomy: Nephrectomy
newdx: Diagnosis group
pfat: % fat mass
plean: % lean mass
pou80: Impaired cardiorespiratory fitness
quadz: Quadricep strength zscore
riskydrk: Risky drinking
sepe7: Septal e’ <7 cm/sec
sixmpyn: 6 Mercaptopurine
smk: Smoking status
stime: Time since diagnosis
strainroc: GLS >=1.5
thiaz: Thiazide diuretics
thoracotomy: Thoractomy
vi34: Left atrial volume index >34 ml/m2
vincyn: Vincristine
week_min_pa: Weekly minutes physcial activity

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