PanTheraDB

This database contains the predictions of synergy scores between triplets of more than 100 drugs treating the cell-lines from the NCI60.

Columns:

NSC1: The NSC of the first drug found in the triplet
NSC2: The NSC of the second drug found in the triplet
NSC3: The NSC of the third drug found in the triplet
CELL_NAME: The name of the treated cell-line
Bliss: The synergy score (ComboScore_{1 /to 3} defined by MEAN(PREDICTED - EXPECTED_BLISS) using the best performing model. Where EXPECTED_BLISS uses the multiplicative survival principle based on the individual dose-responses against each drug in the triplet and MEAN represents the average over the different combinations of concentrations.
Multi: The synergy score (ComboScore_{2 /to 3} defined by MEAN(PREDICTED - EXPECTED_MULTI) using the best performing model. Where EXPECTED_MULTI is defined as the minimum over the three possible pair-single drug combinations in the triplet, using the multiplicative survival principle.
{synergy}_q{XX}: Quantile XX for the synergy aggregated over an ensemble containing 10 models