A Multidisciplinary Approach to Diagnosing and Managing Drug-Induced Liver Injury: The Role of Radiology, Pharmacotherapy, and Biomarkers in a Tertiary Hospital

Background : Drug-Induced Liver Injury (DILI) is a significant cause of acute liver failure and often requires a multidisciplinary approach for accurate diagnosis and effective management.  
 Objective : This study aimed to evaluate the combined role of radiological imaging, biomarkers, and pharmacotherapy in diagnosing and managing DILI in a tertiary hospital.  
 Methods : A retrospective observational study was conducted on 120 patients diagnosed with DILI. Radiological findings, biomarker levels (ALT, AST, bilirubin, cytokeratin-18, microRNA-122), and pharmacotherapy interventions were collected and analyzed.  
 Results : Hepatomegaly (35%) and fatty liver (25%) were the most common radiological findings, while ALT and AST elevations were observed in over 80% of patients. Emerging biomarkers, such as cytokeratin-18, were elevated in 80% of cases. Discontinuation of the offending drug led to recovery in 85% of patients, with N-acetylcysteine and corticosteroids showing positive outcomes in specific cases.  
 Conclusion : The integration of radiological imaging, biomarkers, and pharmacotherapy offers a comprehensive approach to diagnosing and managing DILI. Early intervention and a multidisciplinary strategy are critical for improving patient outcomes.