A Prospective Correlation between Vitamin D Levels and Anaemia in Pregnant women in Southern Rajasthan
Creators
- 1. Resident, Dept. of Pathology, Pacific Institute of Medical Sciences, Umarda, Udaipur
- 2. Assistant Professor, Dept. of Opthalmology, Pacific Institute of Medical Sciences, Umarda, Udaipur
- 3. Assistant Professor, Dept. of Radiodiagnosis, Pacific Institute of Medical Sciences, Umarda, Udaipur
- 4. Assistant Professor, Dept. of Biochemistry, Pacific Institute of Medical Sciences, Umarda, Udaipur
- 5. Professor, Dept. of Paediatrics, Pacific Institute of Medical Sciences, Umarda, Udaipur
- 6. Associate Professor, Dept. of Obstetrics and Gynaecology Pacific Institute of Medical Sciences, Umarda, Udaipur
Description
Aim: To elucidate correlation between serum vitamin D levels and iron status in pregnant women and to generate hypothesis for supplementation of vitamin D in iron deficient patients. Methods: It is a prospective observational study of 100 pregnant women, recruited at the Dept of OBGY at Pacific Institute of Medical Sciences, Umarda, Udaipur. Descriptive analysis was performed for the demographic characteristics. Spearman’s correlation test was used to determine the strength of correlation between vitamin D and the complete blood count parameters. Each outcome variables whose levels were with a P (< 0.05) is significant. Results: For the 100 recruited patients, the mean haemoglobin level was 9.35±0.89 g/dL, iron at 73.0±15.3 microgram/dL, ferritin at 13.0±3.8 ng/mL. There was a moderate positive correlation observed between vitamin D and haemoglobin (rs = 0.49, n = 101 p< 0.001). A strong positive correlation was noted between vitamin D and iron (rs = 0.788, p< 0.000), transferrin (rs = 0.740, p< 0.001), ferritin (r = 0.783, p< 0.001), hematocrit (r = 0.729, p< 0.001). A strong negative population of pregnant women, it is suggestive that the low vitamin D levels are correlated with lower hemoglobin and ferritin levels. Further investigations needs to be conducted to elucidate whether there is a direct causal effect of vitamin D deficiency and iron deficiency anaemia.
Abstract (English)
Aim: To elucidate correlation between serum vitamin D levels and iron status in pregnant women and to generate hypothesis for supplementation of vitamin D in iron deficient patients. Methods: It is a prospective observational study of 100 pregnant women, recruited at the Dept of OBGY at Pacific Institute of Medical Sciences, Umarda, Udaipur. Descriptive analysis was performed for the demographic characteristics. Spearman’s correlation test was used to determine the strength of correlation between vitamin D and the complete blood count parameters. Each outcome variables whose levels were with a P (< 0.05) is significant. Results: For the 100 recruited patients, the mean haemoglobin level was 9.35±0.89 g/dL, iron at 73.0±15.3 microgram/dL, ferritin at 13.0±3.8 ng/mL. There was a moderate positive correlation observed between vitamin D and haemoglobin (rs = 0.49, n = 101 p< 0.001). A strong positive correlation was noted between vitamin D and iron (rs = 0.788, p< 0.000), transferrin (rs = 0.740, p< 0.001), ferritin (r = 0.783, p< 0.001), hematocrit (r = 0.729, p< 0.001). A strong negative population of pregnant women, it is suggestive that the low vitamin D levels are correlated with lower hemoglobin and ferritin levels. Further investigations needs to be conducted to elucidate whether there is a direct causal effect of vitamin D deficiency and iron deficiency anaemia.
Files
IJPCR,Vol16,Issue9,Article92.pdf
Files
(340.0 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:fa4e1767a5cfd571986cf6a9122530b3
|
340.0 kB | Preview Download |
Additional details
Dates
- Accepted
-
2024-09-18
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue9,Article92.pdf
- Development Status
- Active
References
- 1. Nair R, Maseeh A. Vitamin D: The "sunshine" vitamin. J Pharmacol Pharmacother.2012;3(2): 118-26. 2. Kumari R, Bharti RK, Singh K, Sinha A. Prevalence of Iron Deficiency and Iron Deficiency Anaemia in Adolescent Girls in a Tertiary Care Hospital. J Clin DiagnosticRes. 2017;11(8):1 0- 2. 3. Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for hu-man health. J Res Med Sci. 2014;19(2):164-74. 4. Smith EM, Tangpricha V. HHS Public Access. Curr Opin Endocrinol Diabetes Obes. 2015;22 (6):43208. 5. Santoro D, Caccamo D, Lucisano S, Buemi M, Sebekova K,Teta D, et al. Interplay of vitamin D, erythropoiesis and the renin-angiotensin system. Biomed Res Int. 2015; 2015:145828. 6. SuhYJ, Lee JE, Lee DH,Yi HG, Lee MH, Kim CS, et al. Prevalence and Relation-ships of Iron Deficiency Anemia with Blood Cadmium and Vitamin D Levels in Korean Women. J Korean Med Sci. 2016;(31):25-32. 7. Qader EA, Alkhateeb NE. Vitamin D Status in Children with Iron Deficiency and/or Anemia. Int J Pediatr. 2016;4(9):3571-77. 8. Lee JA, Hwang JS, Hwang IT, Kim DH, Seo JH, Lim JS. Low Vitamin D Levels Are Associated with Both Iron Deficiency and Anemia in Children and Adoles- cents. Pediatr Hematol Oncol. 2015;32(2):99-108. 9. Hollis B, Johnson D. Vitamin D supplementation during pregnancy: Double blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res.2011;26(10):2341-5 7. 10. Bener A, Salameh KM, Yousafzai MT, Saleh NM. Pattern of MaternalComplicationsand Low Birth Weight: Associated Risk Factors among Highly Endogamous Women. ISRN Obstet Gynecol. 2012; 2012:540495. 11. Bener A, Abdulla OAA, Al-Hamaq, Saleh NM. Association between vitamin D insufficiency and adverse pregnancy outcome: global comparisons. IntJWomensHealth. 2013;5(9):5 23-31. 12. Sim JJ, Lac PT, Liu ILA, Meguerditchian SO, Kumar VA, Kujubu DA, et al. Vitamin Ddeficiency and anemia: A cross-sectional study. Ann Hematol. 2010;89(5):447-52. 13. Zughaier SM, Alvarez JA, Sloan JH, Konrad RJ, TangprichaV.The role of vitamin Din regulating the iron-hepcidin-ferroportin axisin monocytes. J ClinTransl Endo-crinol. 2014;1(1):e1 9-25. 14. Langer AL, Ginzburg YZ. Role of hepcidin-ferroportin axis in the pathophysiology, diagnosis and treatment of anemia of chronic inflammation. Hemodial Int. 2017;21(6):S37-46. 15. Webb AR, Pilbeam C, Hanafin N, Holick MF. An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentra- tions of 25-hydroxyvitamin D in an elderly nursing home population in Boston. Am J Clin Nutr. 1990;51(6):1075-81. 16. Wacker M, Holick MF. Sunlight and Vitamin D. A global perspective for health. Dermatoendocrinol. 2013;5(1):51-108. 17. Alvarez JA,Wasse H,Tangpricha V, Disease K, Quality O. Vitamin D supplemen-tation in predialysis chronic kidney disease - A systematic review. Dermatoen- docrinol. 2012;4 (2):118- 27. 18. Bikle DD.Vitamin D insufficiency/deficiency in gastrointestinal disorders. J Bone Miner Res. 2007;22 (SUPPL 2):50-4. 19. Bodnar LM, Simhan HN, Powers RW, Frank MP, Cooperstein E, Roberts JM.High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. J Nutr. 2007;137(2):447-52. 20. Merewood A, Mehta SD, Chen TC, Bauchner H, Holick MF. Association between vitamin D deficiency and primary cesarean section. J Clin Endocrinol Metab. 2009;94(3):940-5. 21. Bowyer L, Catling-Paull C, Diamond T, HomerC, Davis G, Craig ME. Vitamin D,PTH and calcium levels in pregnant women and their neonates. Clin Endocrinol(Oxf). 2009;70 (3):372- 7. 22. Harinarayan CV, Holick MF, Prasad U V, Vani PS, Himabindu G. Vitamin D statusand sun exposure in India. Dermatoendocrinol. 2013;5(1): 130-41. 23. Lips P. Interaction between vitamin D and calcium. Scand J Clin Lab Invest Suppl. 2012; 72(243):60-4. 24. Thomas CE, Guillet R, Queenan RA, Cooper EM, Kent TR, Pressman EK, et al. Vitamin D status is inversely associated with anemia and serum erythropoietin during pregnancy. Am J Clin Nutr. 2015;102(5):1088-95. 25. Iraj B, Ebneshahidi A, Askari G. Vitamin D deficiency, prevention and treatment. Int J Prev Med. 2012;3(10):733-6. 26. Bener A, Al-Ali M, Hoffmann GF. High prevalence of vitamin D deficiency in young children in a highly sunny humid country: a global health problem. Minerva Pediatr. 2009;61(1):1 5-22.