Effect of Bone Marrow Aspirate Concentrate on Mixture of Fibrin Glue and Xenograft in Treatment of Critical Sized Periapical Bone Defects (Clinical and Radiographic Study)

ABSTRACT: Objective: The aim of this research was to evaluate bone regeneration capacity of a mixture of
Fibrin glue and Xenogeneic bone graft versus a mixture of BMAC, Fibrin glue and Xenogeneic bone in
critical sized periapical bone defects. Materials and methods: Sixteen patients randomly and equally
divided into two groups; Group I: eight patients with critical periapical bone defects were grafted by a
mixture of fibrin glue and xenograft. Group II: eight patients with critical periapical bone defects were
grafted by a mixture of BMAC, fibrin glue and xenograft. Assessment of pain was done on a Visual
Analogue Scale (VAS) immediate, 3 days and 1 week post-operatively. Radiographic evaluation: for the
bone density, volumetric changes and defect dimensions measurement between study groups. Results: the
highest mean score on visual analogue scale was found in (Group I), while the lowest mean score was found
in (Group II). Group (II) experienced a significant positive change in defect dimensions, in bone density and
defect volume which increase by time in bone density over group (I) till the end of our follow up time which
is 6 months. Conclusion: MSCs present in BMAC promote bone regeneration and improve the density of
regenerated bone.
Keywords: bone marrow aspirate concentrate, fibrin glue, critical bone defect, xenograft, bone regeneration