Evaluation of Letrozole as Suitable Ovulating Induction Agent in Patients with PCOS Induced Infertility
- 1. Assistant Professor, Department of Obstetrics & Gynecology, Nalanda Medical College and Hospital, Patna, Bihar, India
- 2. Assistant Professor, Department of obstetrics & Gynecology, Nalanda Medical College and Hospital, Patna, Bihar, India
Description
Aim: To compare the pathological nature of infertility amongst the female population in the Indian subcontinent. Material & Method: The main source of data for this study are the women with primary and secondary infertility with anovulation attending the Department of Obstetrics & Gynecology, Nalanda Medical College and Hospital, Patna, Bihar, India. This is a prospective study with a total of 200 women satisfied the inclusion and exclusion criteria of the study. The present study consists of cases of infertility due to anovulation which were thoroughly evaluated before the diagnosis of anovulation was confirmed. Results: In this study mean age of the patients were 28.0 years and mean age of husbands were 32.4 year. 105 patients underwent diagnostic hysterolaparoscopy with chromopertubation + ovarian drilling. Conclusion: Letrozole can be considered as suitable ovulating induction agent in patients with PCOS induced infertility. It is a better drug in terms of mono follicular ovulation and better endometrial thickness than other ovulation induction agents. It has high ovulation rate with significant conception rate, with only drawbacks being miscarriages.
Abstract (English)
Aim: To compare the pathological nature of infertility amongst the female population in the Indian subcontinent. Material & Method: The main source of data for this study are the women with primary and secondary infertility with anovulation attending the Department of Obstetrics & Gynecology, Nalanda Medical College and Hospital, Patna, Bihar, India. This is a prospective study with a total of 200 women satisfied the inclusion and exclusion criteria of the study. The present study consists of cases of infertility due to anovulation which were thoroughly evaluated before the diagnosis of anovulation was confirmed. Results: In this study mean age of the patients were 28.0 years and mean age of husbands were 32.4 year. 105 patients underwent diagnostic hysterolaparoscopy with chromopertubation + ovarian drilling. Conclusion: Letrozole can be considered as suitable ovulating induction agent in patients with PCOS induced infertility. It is a better drug in terms of mono follicular ovulation and better endometrial thickness than other ovulation induction agents. It has high ovulation rate with significant conception rate, with only drawbacks being miscarriages.
Files
IJPCR,Vol14,Issue5,Article87.pdf
Files
(107.0 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:6a9960d5a3728abbc77c675358d0b46f
|
107.0 kB | Preview Download |
Additional details
Dates
- Accepted
-
2022-05-15
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue5,Article87.pdf
- Development Status
- Active
References
- 1. Bhatnagar AS. The Early Days of Letrozole. Breast Cancer Res Treat. 2007:105(Suppl 1):3–5. 2. Goss PE, Ingle JN, Martino S, Robert NJ, Muss HB, Piccart MJ, et al. A Randomized Trial of Letrozole in Postmenopausal Women After Five Years of Tamoxifen Therapy for EarlyStage Breast Cancer. N Engl J Med. 2003:349:1793–802. 3. Bhatnagar AS, Batzl C, Häusler A, Nogués V. The Role of Estrogen in the Feedback Regulation of FollicleStimulating Hormone Secretion in the Female Rat. J Steroid Biochem Mol Biol. 1993: 47:161–6. 4. Mitwally MFM, Casper RF. Aromatase Inhibition A Novel Method of Ovulation Induction in Women withPolycystic Ovary Syndrome. Reprod Technol. 2000:10:244–7. 5. R. Azziz, K.S. Woods, R. Reyna, et al., The prevalence and features of the polycystic ovary syndrome in an unselected population, J. Clin. Endocrinol. Metab. 2004:89: 2745– 2749, 6. H. Teede, A. Deeks, L. Moran, Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan, BMC Med. 2010: 8: 41. 7. F.R. Tehrani, M. Simbar, M. Tohidi, et al., The prevalence of polycystic ovary syndrome in a community sample of Iranian population: Iranian PCOS prevalence study, Reproductive Biol. Endocrinol.: RB & E. 2011:9: 39. 8. M. Hajishafiha, M. Dehghan, N. Kiarang, et al., Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome, Drug Des. Devel. Ther. 2014:3 (7): 1427– 1431, 9. M. Brassard, Y. AinMelk, J.P. Baillargeon, Basic infertility including polycystic ovary syndrome, Med. Clin. North Am. 2008:92:1163–1192. 10. Vander Borght M, Wyns C. Fertility and infertility: Definition and epidemiology. Clinical biochemistry 2018; 62:2-10. 11. Drosdzol A, Skrzypulec V. Evaluation of marital and sexual interactions of Polish infertile couples. The journal of sexual medicine 2009; 6:3335-46. 12. Parveen S, Khanam M. Role of combined diagnostic laparoscopy and simultaneous diagnostic hysteroscopy for evaluation of female subfertility factors. J Surg Pak (International) 2010; 15:44-7. 13. Franik S, Kremer JA, Nelen WL, Farquhar C. Aromatase inhibitors for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2014 Feb 24;(2):CD010287. 14. Begum MR, Ferdous J, Begum A, Quadir E. Comparison of efficacy of aromatase inhibitor and clomiphene citrate in induction of ovulation in polycystic ovarian syndrome. Fertil Steril. 2009 Sep;92(3):853-857. 15. R. Davar, M. Javedani, M.H. Fallahzadeh, Metforminletrozole in comparison with Metforminclomiphene citrate in clomipheneresistance PCOS patients undergoing IUI, Iranian J. Reproductive Med. 2011; 9:31–36. 16. R.S. Legro, R.G. Brzyski, M.P. Diamond, et al., for the National Institute of Child Health and Human Development (NICHD) Reproductive Medicine Network. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome, NEJM. 2014; 371(2):119–129. 17. S. Dehbashi, S. Dehbashi, T. Kazerooni, et al., Comparison of the effects of letrozole and clomiphene citrate on ovulation and pregnancy rate in patients with polycystic ovary syndrome, Iranian J. Med. Sci. 2009; 34:23–28. 18. Siddiqui M, Chowdhury T. Letrozole for Induction of Ovulation in PCOS Patients: Resistant to Clomiphene Citrate. South Asian Federation of Obstetrics and Gynecology 2010; 2:99- 103. 19. Rosenfield RL: Adolescent anovulation: maturational mechanisms and implications. The Journal of Clinical Endocrinology & Metabolism 2013; 98:3572-83. 20. Harvey, D. F. Physician Burnout Quality of Life/ Wellness Resource Pilot Program. Journal of Medical Research and Health Sciences, 2020:3(2), 886–912.