RAPID AND AN EFFICIENT ONE-POT THREE-COMPONENT SYNTHESIS OF ISOXAZOLES PROMOTED BY CAS

A straightforward, practical, and economical process for producing isoxazole derivatives is described. It makes use of ethylacetoacetate, hydroxylamine hydrochloride, and substituted aromatic aldehydes with promoted camphor sulfonic acid as a catalyst in a solvent. No toxic organic solvents are used in the current procedure. Shortest reaction time, high product yields, easy work-up process, and non-chromatographic product purification are only a few of this catalysts encouraging reaction response characteristics. The derivatives of desired compounds were analyzed advanced spectroscopic data by ¹H NMR, ¹³CNMR and mass spectrometry was used to verify the products structures. Products were chosen, and their antibacterial activity was examined.