Implantation of abdominal imaging windows on the mouse liver

This video describes the surgical process of implanting an abdominal imaging window (AIW) on the liver of mice. This window can be used for acute or longitudinal imaging. All experiments have been reviewed and approved by the local authorities (Landesdirektion Sachsen).

Implantation of chronic abdominal windows allows for microscopical investigation of highly dynamic processes in physiological and pathological circumstances and is generally tolerated well by experimental animals. It enables insights which otherwise could only be obtained using high numbers of experimental animals. The method can be regarded as reduction approach in terms of 3R implementation.

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