A Comparative Study of Maternal and Perinatal Outcome Between Normal Pregnant Women and Women with First Trimester Vaginal Bleeding
- 1. Postgraduate Resident, Dept. of OBGY, Narayan Medical College, Sasaram, Bihar
- 2. Assistant Professor, Dept. of OBGY, Narayan Medical College, Sasaram, Bihar
- 3. Senior Resident, Dept. of OBGY, Narayan Medical College, Sasaram, Bihar
Description
Introduction: First trimester bleeding may indicate an underlying placental dysfunction, which may manifest later in pregnancy causing adverse outcomes such as increased risk of pre-eclamptic toxemias, preterm delivery, prelabour rupture of membranes (PROM), and IUGR. It is also known that maternal age, systemic diseases such as diabetes mellitus, hypothyroidism, infertility treatment, thrombophilia, maternal weight, and uterine structural anomalies increase the risk of abortus imminens. Aim and objective: To establish the relation between first trimester vaginal bleeding and its effect on maternal and fetal outcome. Material and methods: This study is a comparative cohort study. I included 100 women aged between 18-45 years with first trimester vaginal bleeding as case group, who met the inclusion and exclusion criteria and 100 normal pregnant women without first trimester vaginal bleeding as control. All the women in the study group were followed from the first visit till delivery. The characteristics of all the patients related to their age, gravidity, period of gestation, duration of bleed, ultrasound results, duration of hospital stay, treatment modalities and final fetal and maternal outcome were determined, and data were collected on the basis of proforma. Result: In our study 21% patients had abortion in cases group whereas, 9% had abortion in control group, 62% had Full term vaginal delivery in cases whereas, 80% had full term vaginal delivery in control group 17% delivered preterm in case group as compared to 11% in control group. These differences were statistically significant with p value <0.02. There was statistically significant difference between cases and control for the mode of delivery. Majority of patients, about 64% in cases and 71% in control had vaginal delivery whereas 15% of cases and 20% of control had caesarean section. Conclusion: First trimester vaginal bleeding can be a predicting factor for adverse outcome of mother and infant. It is necessary to increase the knowledge of pregnant women in this regard for observation. Also, because the clinical intervention of attentive obstetrician has important role in not only, the continuation of pregnancy but also decreasing fetal complications in these high-risk pregnancies.
Abstract (English)
Introduction: First trimester bleeding may indicate an underlying placental dysfunction, which may manifest later in pregnancy causing adverse outcomes such as increased risk of pre-eclamptic toxemias, preterm delivery, prelabour rupture of membranes (PROM), and IUGR. It is also known that maternal age, systemic diseases such as diabetes mellitus, hypothyroidism, infertility treatment, thrombophilia, maternal weight, and uterine structural anomalies increase the risk of abortus imminens. Aim and objective: To establish the relation between first trimester vaginal bleeding and its effect on maternal and fetal outcome. Material and methods: This study is a comparative cohort study. I included 100 women aged between 18-45 years with first trimester vaginal bleeding as case group, who met the inclusion and exclusion criteria and 100 normal pregnant women without first trimester vaginal bleeding as control. All the women in the study group were followed from the first visit till delivery. The characteristics of all the patients related to their age, gravidity, period of gestation, duration of bleed, ultrasound results, duration of hospital stay, treatment modalities and final fetal and maternal outcome were determined, and data were collected on the basis of proforma. Result: In our study 21% patients had abortion in cases group whereas, 9% had abortion in control group, 62% had Full term vaginal delivery in cases whereas, 80% had full term vaginal delivery in control group 17% delivered preterm in case group as compared to 11% in control group. These differences were statistically significant with p value <0.02. There was statistically significant difference between cases and control for the mode of delivery. Majority of patients, about 64% in cases and 71% in control had vaginal delivery whereas 15% of cases and 20% of control had caesarean section. Conclusion: First trimester vaginal bleeding can be a predicting factor for adverse outcome of mother and infant. It is necessary to increase the knowledge of pregnant women in this regard for observation. Also, because the clinical intervention of attentive obstetrician has important role in not only, the continuation of pregnancy but also decreasing fetal complications in these high-risk pregnancies.
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IJPCR,Vol14,Issue6,Article5.pdf
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Additional details
Dates
- Accepted
-
2022-05-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue6,Article5.pdf
- Development Status
- Active
References
- 1. Kamble PD, Bava A, Shukla M, Nandanvar YS. Original ResearchArticle First trimester bleeding and pregnancy outcome. 2017;6(4):1484–7. 2. Patel N, Patel M, Shah S, Jani S, Patel J, Shah J. Study of outcome of pregnancy in patients with firsttrimester bleeding per vaginum. Int J Adv Med. 2014;1(3):230-7. 3. Hokabaj S, Rashmi M, Roy P, Shanthi S, Karat C, Garg R. A prospective cohort study of maternal and perinatal outcome in pregnancy with firsttrimester vaginal bleeding. J SAFOG. 2018;10(1):49–53. 4. Kangjam P, Baghel S, Akoijam U. Study of Maternal Outcome in Women with First Trimester Vaginal Bleedinga Comparative Analysis. J Evol Med Dent Sci. 2018;7(07):919–21. 5. Agrawal S, Khoiwal S, Jayant K, Agarwal R. Predicting adverse maternal and perinatal outcome after threatened miscarriage. Open J Obstet Gynecol. 2014;04(01):1–7. 6. Suganya K, Subbarayan LM. Maternal and perinatal outcomes in women with first trimester vaginal bleeding. Int J Reprod Contraception, Obstet Gynecol. 2019;8(11):4320-6. 7. Gollapalli DS, Gunda DJ. Pregnancy outcome in women with first-trimester bleeding per vaginum. Int J Clin Obstet Gynaecol. 2020;4(2):321–3.8. Lewis P, Pimple P. A study on fetomaternal outcome in first trimester bleeding per vaginum, Global Journal for Research Analysis, 2017;69:56–7. 9. Jharaik H, Sharma A, Chandel A, Sharma R. Evaluation of cases with first trimester bleeding and its outcome. Int J Clin Obstet Gynaecol. 2019;3(4):203–5. 10. H. S. K, K. R. A study on pregnancy outcome in patients with first trimester vaginal bleeding. Int J Reprod Contraception, Obstet Gynecol. 2019;8(3):820. 11. Gaur S, Khajotia S, Chandra S, Falodia S. Prospective case–control study to predict the obstetrical (Maternal and fetal) outcome after first trimester bleeding. J SAFOG. 2017;9(3):255–9. 12. Sonal, Anjana Sinha, Geeta Sinha, Pregnancy outcome in patients with first trimester vaginal bleeding: an observational study, International Journal of Health and Clinical Research, 2020; 3(7):208-211. 13. Tsikouras P, Koukouli Z, Liberis A, Manav B, Bouschanetzis C, Naoumis P, et al. Late Αntepartum Ηemorrhage and Neonatal Outcome: A Retrospective Study. Open J Obstet Gynecol. 2016;06(02):107–16. 14. Quraishi AUN, Khurshid R, Andrabi SA, Quraishi KA. Pregnancy outcome after first trimester vaginal bleeding. Int J Reprod Contraception, Obstet Gynecol. 2020;9(4):1695-9. 15. Lykke JA, Dideriksen KL, Lidegaard Ø, Langhoff-Roos J. First-trimester vaginal bleeding and complications later in pregnancy. Obstet Gynecol Surv. 2010;65(9):563–4. 16. Patil A, Singh S, Patil R. Evaluation of perinatal outcome in early and late pregnancy haemorrhage in tertiary care centre. MedPulse Int J Gynaecol. 2020;14(1):16–24. 17. Moon A, Shabbir S. Pregnancy outcome in women presenting with per vaginal bleeding in first trimester of pregnancy. Int J Reprod Contraception, Obstet Gynecol. 2021;10(2):439-44. 18. Lokhande R, Gedam B, Shah Y, Tandon M, Bansod PY. Rationale for near total thyroidectomy in patients with nodular goitre. Int J Biomed Adv Res IJBAR Int J Biomed Adv Res J. 2015;6(605):427–30. 19. Desai M, Phillips-Howard PA, Odhiambo FO, et al. An analysis of pregnancy-related mortality in the KEMRI/CDC health and demographic surveillance system in western Kenya. PLoS One. 2013;8(7):e68733. 20. Saraswat L, Bhattacharya S, Maheshwari A, Bhattacharya S. Maternal and perinatal outcome in women with threatened miscarriage in the first trimester: a systematic review. BJOG 2010 Feb;117(3):245-257. 21. Hosseini MS, Yaghoubipour S. Late pregnancy outcome in women with vaginal bleeding in their first trimester. J Obstet Gynaecol India 2013 Oct;63(5):31-7. 22. Kanmaz AG, Inan AH, Beyan E, Budak A. The effects of threatened abortions on pregnancy outcomes. Ginekol Pol. 2019;90(4):195–200. 23. Chand S, Salman A, Abbassi RM, Siyal AR, Ahmad FM, Leghari AL, et al. Factors Leading to Meconium Aspiration Syndrome in Term- and Post-term Neonates. Cureus. 2019;11(9):5–11.