Published December 25, 2018 | Version v1
Dataset Open

GenCoNet

Description

GenCoNet – A Graph Database for the Analysis of Comorbidities by Gene Networks

Alban Shoshi, Ralf Hofestädt, Olga Zolotareva, Marcel Friedrichs, Alex Maier, Vladimir A. Ivanisenko, Victor E. Dosenko, Elena Yu Bragina

The prevalence of comorbid diseases poses a major health issue for millions of people worldwide and an enormous socio-economic burden for society. The molecular mechanisms for the development of comorbidities need to be investigated. For this purpose, a workflow system was developed to aggregate data on biomedical entities from heterogeneous data sources. The process of integrating and merging all data sources of the workflow system was implemented as a semi-automatic pipeline that provides the import, fusion, and analysis of the highly connected biomedical data in a Neo4j database GenCoNet. As a starting point, data on the common comorbid diseases essential hypertension and bronchial asthma was integrated. GenCoNet (https://genconet.kalis-amts.de) is a curated database that provides a better understanding of hereditary bases of comorbidities.

Results

The following results table was extracted from the Neo4j database. It represents all integrated drugs that treat either asthma or essential hypertension and are tagged as approved in DrugBank. Additional drugs contained in the database but not listed here are either not approved or have contraindicates but no treats relationships.

DrugBank ID Drug Name Treats Contraindicates Induces
DB09273 Doxofylline Asthma    
DB13139 Levosalbutamol Asthma    
DB08979 Fenspiride Asthma    
DB09076 Umeclidinium bromide Asthma    
DB00043 Omalizumab Asthma    
DB00180 Flunisolide Asthma    
DB00221 Isoetarine Asthma    
DB00332 Ipratropium bromide Asthma    
DB00394 Beclometasone Asthma    
DB00443 Betamethasone Asthma    
DB00471 Montelukast Asthma    
DB00549 Zafirlukast Asthma    
DB00651 Dyphylline Asthma    
DB00716 Nedocromil Asthma    
DB00744 Zileuton Asthma    
DB00764 Mometasone Asthma    
DB00824 Enprofylline Asthma    
DB00816 Orciprenaline Asthma    
DB00871 Terbutaline Asthma    
DB00920 Ketotifen Asthma    
DB00983 Formoterol Asthma    
DB00938 Salmeterol Asthma    
DB01001 Salbutamol Asthma    
DB00986 Glycopyrronium bromide Asthma    
DB01025 Amlexanox Asthma    
DB01003 Cromoglicate Asthma    
DB01222 Budesonide Asthma    
DB01064 Isoprenaline Asthma    
DB01288 Fenoterol Asthma    
DB01366 Procaterol Asthma    
DB01407 Clenbuterol Asthma    
DB01291 Pirbuterol Asthma    
DB01410 Ciclesonide Asthma    
DB01411 Pranlukast Asthma    
DB01408 Bambuterol Asthma    
DB01409 Tiotropium Asthma    
DB01656 Roflumilast Asthma    
DB05039 Indacaterol Asthma    
DB08906 Fluticasone furoate Asthma    
DB08957 Hexoprenaline Asthma    
DB06612 Mepolizumab Asthma    
DB08897 Aclidinium Asthma    
DB09082 Vilanterol Asthma    
DB09080 Olodaterol Asthma    
DB00277 Theophylline Asthma   Essential Hypertension
DB00588 Fluticasone Propionate Asthma   Essential Hypertension
DB01223 Aminophylline Asthma   Essential Hypertension
DB01303 Oxtriphylline Asthma   Essential Hypertension
DB05266 Ibudilast Asthma   Essential Hypertension
DB00620 Triamcinolone Asthma Essential Hypertension  
DB01363 Ephedra Asthma Essential Hypertension  
DB00668 Epinephrine Asthma Essential Hypertension  
DB00860 Prednisolone Asthma Essential Hypertension  
DB00436 Bendroflumethiazide Essential Hypertension    
DB00457 Prazosin Essential Hypertension    
DB00524 Metolazone Essential Hypertension    
DB00528 Lercanidipine Essential Hypertension    
DB00325 Nitroprusside Essential Hypertension    
DB00343 Diltiazem Essential Hypertension    
DB00381 Amlodipine Essential Hypertension    
DB00384 Triamterene Essential Hypertension    
DB00212 Remikiren Essential Hypertension    
DB00206 Reserpine Essential Hypertension    
DB00226 Guanadrel Essential Hypertension    
DB00214 Torasemide Essential Hypertension    
DB00270 Isradipine Essential Hypertension    
DB00310 Chlorthalidone Essential Hypertension    
DB00275 Olmesartan Essential Hypertension    
DB00177 Valsartan Essential Hypertension    
DB00187 Esmolol Essential Hypertension    
DB09236 Lacidipine Essential Hypertension    
DB09242 Moxonidine Essential Hypertension    
DB01349 Tasosartan Essential Hypertension    
DB01275 Hydralazine Essential Hypertension    
DB08822 Azilsartan medoxomil Essential Hypertension    
DB00590 Doxazosin Essential Hypertension    
DB00575 Clonidine Essential Hypertension    
DB00657 Mecamylamine Essential Hypertension    
DB09026 Aliskiren Essential Hypertension    
DB00629 Guanabenz Essential Hypertension    
DB00880 Chlorothiazide Essential Hypertension    
DB00678 Losartan Essential Hypertension    
DB00695 Furosemide Essential Hypertension    
DB00692 Phentolamine Essential Hypertension    
DB00966 Telmisartan Essential Hypertension    
DB00968 Methyldopa Essential Hypertension    
DB00700 Eplerenone Essential Hypertension    
DB00742 Mannitol Essential Hypertension    
DB00796 Candesartan Essential Hypertension    
DB00808 Indapamide Essential Hypertension    
DB00876 Eprosartan Essential Hypertension    
DB01162 Terazosin Essential Hypertension    
DB01158 Bretylium Essential Hypertension    
DB01116 Trimethaphan Essential Hypertension    
DB01170 Guanethidine Essential Hypertension    
DB01023 Felodipine Essential Hypertension    
DB01018 Guanfacine Essential Hypertension    
DB00999 Hydrochlorothiazide Essential Hypertension    
DB01090 Pentolinium Essential Hypertension    
DB01089 Deserpidine Essential Hypertension    
DB01054 Nitrendipine Essential Hypertension    
DB00492 Fosinopril Essential Hypertension   Asthma
DB00519 Trandolapril Essential Hypertension   Asthma
DB00178 Ramipril Essential Hypertension   Asthma
DB00335 Atenolol Essential Hypertension   Asthma
DB01348 Spirapril Essential Hypertension   Asthma
DB01626 Pargyline Essential Hypertension   Asthma
DB01580 Oxprenolol Essential Hypertension   Asthma
DB01214 Metipranolol Essential Hypertension   Asthma
DB01340 Cilazapril Essential Hypertension   Asthma
DB00264 Metoprolol Essential Hypertension   Asthma
DB09477 Enalaprilat Essential Hypertension   Asthma
DB00622 Nicardipine Essential Hypertension   Asthma
DB00691 Moexipril Essential Hypertension   Asthma
DB00542 Benazepril Essential Hypertension   Asthma
DB00584 Enalapril Essential Hypertension   Asthma
DB00594 Amiloride Essential Hypertension   Asthma
DB00612 Bisoprolol Essential Hypertension   Asthma
DB01197 Captopril Essential Hypertension   Asthma
DB00722 Lisinopril Essential Hypertension   Asthma
DB01193 Acebutolol Essential Hypertension   Asthma
DB01180 Rescinnamine Essential Hypertension   Asthma
DB01029 Irbesartan Essential Hypertension   Asthma
DB00790 Perindopril Essential Hypertension   Asthma
DB04846 Celiprolol Essential Hypertension   Asthma
DB00797 Tolazoline Essential Hypertension   Asthma
DB01115 Nifedipine Essential Hypertension   Asthma
DB04861 Nebivolol Essential Hypertension   Asthma
DB00881 Quinapril Essential Hypertension   Asthma
DB00925 Phenoxybenzamine Essential Hypertension   Asthma
DB00195 Betaxolol Essential Hypertension   Asthma
DB00350 Minoxidil Essential Hypertension   Asthma
DB00661 Verapamil Essential Hypertension   Asthma
DB00421 Spironolactone Essential Hypertension   Asthma
DB00393 Nimodipine Essential Hypertension   Asthma
DB01203 Nadolol Essential Hypertension Asthma Asthma
DB00489 Sotalol Essential Hypertension Asthma Asthma
DB00598 Labetalol Essential Hypertension Asthma Asthma
DB00571 Propranolol Essential Hypertension Asthma Asthma
DB00373 Timolol Essential Hypertension Asthma Asthma
DB01136 Carvedilol Essential Hypertension Asthma Asthma
DB00960 pindolol Essential Hypertension Asthma Asthma

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Additional details

Related works

Is supplement to
Publication: 10.1515/jib-2018-0049 (DOI)